Identification of a pheromone that increases anxiety in rats

DOI Web Site 被引用文献13件 参考文献63件 オープンアクセス
  • Hideaki Inagaki
    Laboratory of Veterinary Ethology, Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan;
  • Yasushi Kiyokawa
    Laboratory of Veterinary Ethology, Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan;
  • Shigeyuki Tamogami
    Technical Research Institute, T. Hasegawa Co., Ltd., Kawasaki-shi, Kanagawa 211-0022, Japan; and
  • Hidenori Watanabe
    Laboratory of Organic Chemistry, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
  • Yukari Takeuchi
    Laboratory of Veterinary Ethology, Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan;
  • Yuji Mori
    Laboratory of Veterinary Ethology, Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan;

説明

<jats:title>Significance</jats:title> <jats:p>Animals communicate with other members of the same species by using pheromones. Rats release a specific odor into the air when they are stressed. Because this stress-related odor increases anxiety in the other rats, it is likely that there are some anxiogenic molecules in this odor. In this study, we have tried to identify these molecules. We discovered that a combination of two molecules, 4-methylpentanal and hexanal, increased anxiety in rats. We concluded that the mixture is a pheromone in rats that can increase anxiety in conspecifics. Furthermore, we proposed that the neural circuit relating to anxiety was only activated when the two molecules were simultaneously perceived by two separate olfactory systems.</jats:p>

収録刊行物

被引用文献 (13)*注記

もっと見る

参考文献 (63)*注記

もっと見る

関連プロジェクト

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ