Social isolation impairs remyelination in mice through modulation of IL‐6
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- Manabu Makinodan
- Department of PsychiatryNara Medical University School of Medicine Nara Japan
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- Daisuke Ikawa
- Department of PsychiatryNara Medical University School of Medicine Nara Japan
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- Yuki Miyamoto
- Department of PharmacologyNational Research Institute for Child Health and Development Tokyo Japan
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- Junji Yamauchi
- Department of PharmacologyNational Research Institute for Child Health and Development Tokyo Japan
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- Kazuhiko Yamamuro
- Department of PsychiatryNara Medical University School of Medicine Nara Japan
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- Yasunori Yamashita
- Department of PsychiatryNara Medical University School of Medicine Nara Japan
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- Michihiro Toritsuka
- Department of PsychiatryNara Medical University School of Medicine Nara Japan
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- Sohei Kimoto
- Department of PsychiatryNara Medical University School of Medicine Nara Japan
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- Kazuki Okumura
- Department of PsychiatryNara Medical University School of Medicine Nara Japan
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- Takahira Yamauchi
- Department of PsychiatryNara Medical University School of Medicine Nara Japan
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- Shin‐ichi Fukami
- Department of PsychiatryNara Medical University School of Medicine Nara Japan
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- Hiroki Yoshino
- Department of PsychiatryNara Medical University School of Medicine Nara Japan
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- Akio Wanaka
- Department of Anatomy and NeuroscienceNara Medical University School of Medicine Nara Japan
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- Toshifumi Kishimoto
- Department of PsychiatryNara Medical University School of Medicine Nara Japan
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説明
Recent studies have revealed that social experience affects myelination. These findings have important implications for disorders that feature abnormal myelination, such as multiple sclerosis (MS), as previous studies have shown that psychosocial stress exacerbates the pathobiology of MS. However, most studies have focused on psychosocial stress during the demyelination phase of MS and have not investigated the effects of social experience on remyelination. Thus, the current study sought to determine whether social experience can alter remyelination after myelin depletion. Myelin in the mouse medial prefrontal cortex was depleted with cuprizone, and the effects of subsequent social isolation on remyelination were evaluated. Remyelination was severely impaired in socially isolated mice. Social isolation also increased IL-6 levels in the medial prefrontal cortex, and administration of an IL-6 inhibitor (ND
収録刊行物
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- The FASEB Journal
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The FASEB Journal 30 (12), 4267-4274, 2016-09-09
Wiley