Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project
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- Delphine Praud
- Department of Clinical Sciences and Community Health, University of Milan
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- Matteo Rota
- Department of Epidemiology, IRCCS – Istituto di Ricerche Farmacologiche Mario Negri, Milan
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- Claudio Pelucchi
- Department of Epidemiology, IRCCS – Istituto di Ricerche Farmacologiche Mario Negri, Milan
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- Paola Bertuccio
- Department of Clinical Sciences and Community Health, University of Milan
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- Tiziana Rosso
- Department of Clinical Sciences and Community Health, University of Milan
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- Carlotta Galeone
- Department of Epidemiology, IRCCS – Istituto di Ricerche Farmacologiche Mario Negri, Milan
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- Zuo-Feng Zhang
- Department of Epidemiology, UCLA Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, California
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- Keitaro Matsuo
- Division of Molecular Medicine
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- Hidemi Ito
- Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
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- Jinfu Hu
- Harbin Medical University, Harbin
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- Kenneth C. Johnson
- Department of Epidemiology and Community Health, University of Ottawa, Ottawa, Ontario
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- Guo-Pei Yu
- Medical Informatics Center, Peking University, Peking, China
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- Domenico Palli
- Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – Istituto per lo Studio e la Prevenzione Oncologica (ISPO), Florence
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- Monica Ferraroni
- Department of Clinical Sciences and Community Health, University of Milan
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- Joshua Muscat
- The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, New York
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- Nuno Lunet
- EPIUnit – Institute of Public Health, University of Porto (ISPUP)
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- Bárbara Peleteiro
- EPIUnit – Institute of Public Health, University of Porto (ISPUP)
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- Reza Malekzadeh
- Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
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- Weimin Ye
- Department of Medical Epidemiology and Biostatistics
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- Huan Song
- Department of Medical Epidemiology and Biostatistics
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- David Zaridze
- Department of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Center, Moscow, Russia
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- Dmitry Maximovitch
- Department of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Center, Moscow, Russia
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- Nuria Aragonés
- Environmental and Cancer Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III
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- Gemma Castaño-Vinyals
- CIBER Epidemiología y Salud Pública (CIBERESP)
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- Jesus Vioque
- CIBER Epidemiología y Salud Pública (CIBERESP)
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- Eva M. Navarrete-Muñoz
- CIBER Epidemiología y Salud Pública (CIBERESP)
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- Mohammadreza Pakseresht
- Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Canada
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- Farhad Pourfarzi
- Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
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- Alicja Wolk
- Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
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- Nicola Orsini
- Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
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- Andrea Bellavia
- Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
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- Niclas Håkansson
- Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
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- Lina Mu
- Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo
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- Roberta Pastorino
- Section of Hygiene – Institute of Public Health, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario ‘Agostino Gemelli’
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- Robert C. Kurtz
- Department of Medicine, Memorial Sloan Kettering Cancer Centre
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- Mohammad H. Derakhshan
- Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
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- Areti Lagiou
- Department of Public Health and Community Health, School of Health Professions, Athens Technological Educational Institute
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- Pagona Lagiou
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
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- Paolo Boffetta
- The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, New York
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- Stefania Boccia
- Section of Hygiene – Institute of Public Health, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario ‘Agostino Gemelli’
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- Eva Negri
- Department of Epidemiology, IRCCS – Istituto di Ricerche Farmacologiche Mario Negri, Milan
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- Carlo La Vecchia
- Department of Clinical Sciences and Community Health, University of Milan
Abstract
<jats:p>Tobacco smoking is a known cause of gastric cancer, but several aspects of the association remain imprecisely quantified. We examined the relation between cigarette smoking and the risk of gastric cancer using a uniquely large dataset of 23 epidemiological studies within the ‘Stomach cancer Pooling (StoP) Project’, including 10 290 cases and 26 145 controls. We estimated summary odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study-specific ORs using random-effects models. Compared with never smokers, the ORs were 1.20 (95% CI: 1.09–1.32) for ever, 1.12 (95% CI: 0.99–1.27) for former, and 1.25 (95% CI: 1.11–1.40) for current cigarette smokers. Among current smokers, the risk increased with number of cigarettes per day to reach an OR of 1.32 (95% CI: 1.10–1.58) for smokers of more than 20 cigarettes per day. The risk increased with duration of smoking, to reach an OR of 1.33 (95% CI: 1.14–1.54) for more than 40 years of smoking and decreased with increasing time since stopping cigarette smoking (<jats:italic toggle="yes">P</jats:italic> for trend<0.01) and became similar to that of never smokers 10 years after stopping. Risks were somewhat higher for cardia than noncardia gastric cancer. Risks were similar when considering only studies with information on <jats:italic toggle="yes">Helicobacter pylori</jats:italic> infection and comparing all cases to <jats:italic toggle="yes">H. pylori</jats:italic>+ controls only. This study provides the most precise estimate of the detrimental effect of cigarette smoking on the risk of gastric cancer on the basis of individual data, including the relationship with dose and duration, and the decrease in risk following stopping smoking.</jats:p>
Journal
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- European Journal of Cancer Prevention
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European Journal of Cancer Prevention 27 (2), 124-133, 2018-03
Ovid Technologies (Wolters Kluwer Health)
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Details 詳細情報について
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- CRID
- 1360004234886212736
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- ISSN
- 09598278
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- Data Source
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- Crossref
- KAKEN