Pyrrole‐imidazole polyamide targeted to break fusion sites in <scp>TMPRSS</scp>2 and <scp>ERG</scp> gene fusion represses prostate tumor growth
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- Daisuke Obinata
- Department of Urology Nihon University School of Medicine Tokyo Japan
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- Akiko Ito
- Department of Urology Nihon University School of Medicine Tokyo Japan
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- Kyoko Fujiwara
- Division of General Medicine Department of Medicine Nihon University School of Medicine Tokyo Japan
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- Ken‐Ichi Takayama
- Department of Anti‐Aging Medicine Graduate School of Medicine The University of Tokyo Tokyo Japan
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- Daisaku Ashikari
- Department of Urology Nihon University School of Medicine Tokyo Japan
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- Yasutaka Murata
- Department of Urology Nihon University School of Medicine Tokyo Japan
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- Kenya Yamaguchi
- Department of Urology Nihon University School of Medicine Tokyo Japan
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- Tomohiko Urano
- Department of Anti‐Aging Medicine Graduate School of Medicine The University of Tokyo Tokyo Japan
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- Tetsuya Fujimura
- Department of Urology Graduate School of Medicine The University of Tokyo Tokyo Japan
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- Noboru Fukuda
- Department of Advanced Medicine and Advanced Research Institute of Sciences and Humanities Nihon University School of Medicine Tokyo Japan
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- Masayoshi Soma
- Division of General Medicine Department of Medicine Nihon University School of Medicine Tokyo Japan
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- Takayoshi Watanabe
- Chiba Cancer Center Research Institute Chiba Japan
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- Hiroki Nagase
- Chiba Cancer Center Research Institute Chiba Japan
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- Satoshi Inoue
- Department of Anti‐Aging Medicine Graduate School of Medicine The University of Tokyo Tokyo Japan
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- Satoru Takahashi
- Department of Urology Nihon University School of Medicine Tokyo Japan
書誌事項
- 公開日
- 2014-09-18
- 資源種別
- journal article
- 権利情報
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- http://creativecommons.org/licenses/by-nc/3.0/
- DOI
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- 10.1111/cas.12493
- 公開者
- Wiley
この論文をさがす
説明
<jats:p>Aberrant overexpression of <jats:styled-content style="fixed-case">ERG</jats:styled-content> induced by the <jats:italic><jats:styled-content style="fixed-case">TMPRSS</jats:styled-content>2‐<jats:styled-content style="fixed-case">ERG</jats:styled-content></jats:italic> gene fusion is likely involved in the development of prostate cancer. Synthetic pyrrole–imidazole (<jats:styled-content style="fixed-case">PI</jats:styled-content>) polyamides recognize and attach to the minor groove of <jats:styled-content style="fixed-case">DNA</jats:styled-content> with high affinity and specificity. In the present study, we designed a <jats:styled-content style="fixed-case">PI</jats:styled-content> polyamide targeting <jats:italic><jats:styled-content style="fixed-case">TMPRSS</jats:styled-content>2‐<jats:styled-content style="fixed-case">ERG</jats:styled-content></jats:italic> translocation breakpoints and assessed its effect on human prostate cancer cells. Our study identified that this <jats:styled-content style="fixed-case">PI</jats:styled-content> polyamide repressed the cell and tumor growth of androgen‐sensitive <jats:styled-content style="fixed-case">LNC</jats:styled-content>aP prostate cancer cells. Targeting of these breakpoint sequences by <jats:styled-content style="fixed-case">PI</jats:styled-content> polyamides could be a novel approach for the treatment of prostate cancer.</jats:p>
収録刊行物
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- Cancer Science
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Cancer Science 105 (10), 1272-1278, 2014-09-18
Wiley