Flamingo, a seven‐pass transmembrane cadherin, cooperates with <scp>N</scp>etrin/<scp>F</scp>razzled in <i><scp>D</scp>rosophila</i> midline guidance

DOI Web Site Web Site PubMed 参考文献76件 オープンアクセス
  • Cristina Organisti
    Max Planck Institute of Neurobiology Sensory Neurogenetics Research Group Am Klopferspitz 18 Martinsried 82152 Germany
  • Irina Hein
    Max Planck Institute of Neurobiology Sensory Neurogenetics Research Group Am Klopferspitz 18 Martinsried 82152 Germany
  • Ilona C. Grunwald Kadow
    Max Planck Institute of Neurobiology Sensory Neurogenetics Research Group Am Klopferspitz 18 Martinsried 82152 Germany
  • Takashi Suzuki
    Department of Bioscience and Biotechnology Tokyo Institute of Technology Nagatsuta 4259 Midori‐ku Yokohama 226‐8501 Japan

書誌事項

公開日
2014-11-30
資源種別
journal article
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1111/gtc.12202
公開者
Wiley

この論文をさがす

説明

<jats:p>During central nervous system development, several guidance cues and receptors, as well as cell adhesion molecules, are required for guiding axons across the midline and along the anterior–posterior axis. In <jats:italic>Drosophila</jats:italic>, commissural axons sense the midline attractants Netrin A and B (Net) through Frazzled (Fra) receptors. Despite their importance, lack of <jats:italic>Net</jats:italic> or <jats:italic>fra</jats:italic> affects only some commissures, suggesting that additional molecules can fulfill this function. Recently, planar cell polarity (PCP) proteins have been implicated in midline axon guidance in both vertebrate and invertebrate systems. Here, we report that the atypical cadherin and PCP molecule Flamingo/Starry night (Fmi/Stan) acts jointly with Net/Fra signaling during midline development. Additional removal of <jats:italic>fmi</jats:italic> strongly increases the guidance defects in <jats:italic>Net/fra</jats:italic> mutants. Rescue and domain deletion experiments suggest that Fmi signaling facilitates commissural pathfinding potentially by mediating axonal fasciculation in a partly homophilic manner. Altogether, our results indicate that contact‐mediated cell adhesion via Fmi acts in addition to the Net/Fra guidance system during axon pathfinding across the midline, underlining the importance of PCP molecules during vertebrates and invertebrates midline development.</jats:p>

収録刊行物

参考文献 (76)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ