Mistimed wheel running interferes with re‐entrainment of circadian <i>Per1</i> rhythms in the mouse skeletal muscle and lung
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- Yujiro Yamanaka
- Department of Physiology Hokkaido University Graduate School of Medicine N‐15, W‐7, Kita‐ku Sapporo 060‐8638 Japan
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- Sato Honma
- Department of Chronomedicine Hokkaido University Graduate School of Medicine N‐15 W‐7 Kita‐ku Sapporo 060‐8638 Japan
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- Ken‐ichi Honma
- Department of Chronomedicine Hokkaido University Graduate School of Medicine N‐15 W‐7 Kita‐ku Sapporo 060‐8638 Japan
書誌事項
- 公開日
- 2016-01-28
- 資源種別
- journal article
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/gtc.12336
- 公開者
- Wiley
この論文をさがす
説明
<jats:p>Previously, we showed the acceleration of re‐entrainment to 8‐h phase‐advanced light/dark cycles (<jats:styled-content style="fixed-case">LD</jats:styled-content>) in the circadian <jats:italic>Per1</jats:italic> expression rhythms of the mouse lung and skeletal muscle by 3‐h wheel running (<jats:styled-content style="fixed-case">WR</jats:styled-content>) at the beginning of shifted dark phase. In the present study, the effects of <jats:styled-content style="fixed-case">WR</jats:styled-content> at the end of shifted dark phase were examined on the re‐entrainment in mice. <jats:styled-content style="fixed-case">LD</jats:styled-content> was advanced by shortening and was delayed by lengthening the first light period in the phase‐advance and phase‐delay protocol, respectively. Shifted <jats:styled-content style="fixed-case">LD</jats:styled-content> was continued for 4 days, which was followed by constant darkness (<jats:styled-content style="fixed-case">DD</jats:styled-content>). <jats:italic>Per1</jats:italic> expression was measured in the cultured tissues obtained on the first day of <jats:styled-content style="fixed-case">DD</jats:styled-content> from mice carrying a bioluminescence reporter of <jats:italic>Per1</jats:italic> expression. In the phase‐advance protocol, re‐entrainment was not influenced by <jats:styled-content style="fixed-case">WR</jats:styled-content> in any circadian rhythm examined. In the phase‐delay protocol, re‐entrainment of the circadian locomotor rhythm was not affected by <jats:styled-content style="fixed-case">WR</jats:styled-content>. However, re‐entrainment of circadian <jats:italic>Per1</jats:italic> rhythm was significantly decelerated in the skeletal muscle and lung. These findings indicate that the effects of <jats:styled-content style="fixed-case">WR</jats:styled-content> on re‐entrainment depend on the time of day and the peripheral tissues. Mistimed <jats:styled-content style="fixed-case">WR</jats:styled-content> interferes with re‐entrainment of circadian rhythms in the lung and skeletal muscle.</jats:p>
収録刊行物
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- Genes to Cells
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Genes to Cells 21 (3), 264-274, 2016-01-28
Wiley
