Involvement of the luteinizing hormone surge in the regulation of ovary and oviduct clock gene expression in mice
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- Momoko Kobayashi
- Graduate School of Animal and Food Hygiene Obihiro University of Agriculture and Veterinary Medicine Obihiro Hokkaido Japan
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- Kaya Watanabe
- Graduate School of Animal and Food Hygiene Obihiro University of Agriculture and Veterinary Medicine Obihiro Hokkaido Japan
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- Ritsuko Matsumura
- The Research Institute for Time Studies Yamaguchi University Yamaguchi Yamaguchi Japan
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- Nozomi Anayama
- Graduate School of Animal and Food Hygiene Obihiro University of Agriculture and Veterinary Medicine Obihiro Hokkaido Japan
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- Akio Miyamoto
- Graduate School of Animal and Food Hygiene Obihiro University of Agriculture and Veterinary Medicine Obihiro Hokkaido Japan
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- Hitoshi Miyazaki
- Gene Research Center University of Tsukuba Tsukuba Ibaraki Japan
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- Koyomi Miyazaki
- Biomedical Research Institute National Institute of Advanced Industrial Science and Technology (AIST) Tsukuba Ibaraki Japan
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- Takashi Shimizu
- Graduate School of Animal and Food Hygiene Obihiro University of Agriculture and Veterinary Medicine Obihiro Hokkaido Japan
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- Makoto Akashi
- The Research Institute for Time Studies Yamaguchi University Yamaguchi Yamaguchi Japan
Description
<jats:title>Abstract</jats:title><jats:p>Circadian dysfunction perturbs the female reproductive cycle. In particular, mice lacking the clock gene <jats:italic>Bmal1</jats:italic> show severe infertility, implying that <jats:styled-content style="fixed-case">BMAL</jats:styled-content>1 plays roles in ovulation and luteinization. Here, we examined temporal changes in clock gene expression in the ovary and oviduct before and during gonadotropin‐induced follicular growth, ovulation, and luteinization in sexually immature mice. While the oviduct did not show a drastic change in clock gene expression, <jats:italic>Bmal1</jats:italic> expression in the ovary was higher than that in control mice during the period from 4 to 16 hr after human chorionic gonadotropin (<jats:styled-content style="fixed-case">hCG</jats:styled-content>) administration. <jats:italic>Bmal1</jats:italic> expression reached a maximum at 16 hr after <jats:styled-content style="fixed-case">hCG</jats:styled-content> administration, when follicle luteinization occurred. In an interesting manner, administration of <jats:styled-content style="fixed-case">hCG</jats:styled-content> to ex vivo‐cultured oviduct triggered a shorter circadian period and inevitably resulted in phase advance. Together, our present data suggest that <jats:styled-content style="fixed-case">LH</jats:styled-content> surge induces continuous expression of <jats:styled-content style="fixed-case">BMAL</jats:styled-content>1 in the mouse ovary and modulates circadian phase in the mouse oviduct.</jats:p>
Journal
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- Genes to Cells
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Genes to Cells 23 (8), 649-657, 2018-06-19
Wiley
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Details 詳細情報について
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- CRID
- 1360004235522302336
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- ISSN
- 13652443
- 13569597
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- Data Source
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- Crossref
- KAKEN