The Prevalence of<i>Helicobacter pylori</i>Virulence Factors in Bhutan, Vietnam, and Myanmar Is Related to Gastric Cancer Incidence
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- Tran Thi Huyen Trang
- Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan
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- Seiji Shiota
- Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan
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- Miyuki Matsuda
- Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan
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- Tran Thanh Binh
- Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan
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- Rumiko Suzuki
- Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan
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- Ratha-korn Vilaichone
- Gastroenterology Unit, Department of Medicine, Thammasat University Hospital, Pathum Thani 12120, Thailand
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- Varocha Mahachai
- GI and Liver Center, Bangkok Medical Center, Bangkok 10310, Thailand
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- Lotay Tshering
- Department of Surgery, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan
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- Ho D. Q. Dung
- Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh, Vietnam
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- Tomohisa Uchida
- Department of Molecular Pathology, Oita University Faculty of Medicine, Yufu 897-5593, Japan
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- Osamu Matsunari
- Department of Gastroenterology, Oita University Faculty of Medicine, Yufu 879-5593, Japan
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- Thein Myint
- Department of Gastroenterology, Yangon General Hospital, Yangon 11131, Myanmar
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- Vu Van Khien
- Department of Gastroenterology, 108 Hospital, Hanoi, Vietnam
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- Yoshio Yamaoka
- Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, Japan
書誌事項
- 公開日
- 2015
- 資源種別
- journal article
- 権利情報
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- http://creativecommons.org/licenses/by/3.0/
- DOI
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- 10.1155/2015/830813
- 10.5281/zenodo.3478855
- 10.5281/zenodo.3478856
- 公開者
- Wiley
この論文をさがす
説明
<jats:p>Gastric cancer is a significant health problem in Asia. Although the prevalence of<jats:italic>Helicobacter pylori</jats:italic>infection is similar in Bhutan, Vietnam, and Myanmar, the incidence of gastric cancer is highest in Bhutan, followed by Vietnam and Myanmar. We hypothesized that<jats:italic>H. pylori</jats:italic>virulence factors contribute to the differences. The status of<jats:italic>cagA</jats:italic>,<jats:italic>vacA</jats:italic>,<jats:italic>jhp0562</jats:italic>, and<jats:italic>β</jats:italic>-<jats:italic>(1,3)galT(jhp0563)</jats:italic>was examined in 371<jats:italic>H. pylori</jats:italic>-infected patients from Bhutan, Vietnam, and Myanmar. Each virulence factor could not explain the difference of the incidence of gastric cancer. However, the prevalence of quadruple-positive for<jats:italic>cagA</jats:italic>,<jats:italic>vacA</jats:italic>s1,<jats:italic>vacA</jats:italic>m1, and<jats:italic>jhp0562</jats:italic>-positive/<jats:italic>β</jats:italic>-<jats:italic>(1,3)galT</jats:italic>-negative was significantly higher in Bhutan than in Vietnam and Myanmar and correlated with gastric cancer incidence. Moreover, gastritis-staging scores measured by histology of gastric mucosa were significantly higher in quadruple-positive strains. We suggest that the<jats:italic>cagA</jats:italic>,<jats:italic>vacA</jats:italic>s1,<jats:italic>vacA</jats:italic>m1, and<jats:italic>jhp0562</jats:italic>-positive/<jats:italic>β</jats:italic>-<jats:italic>(1,3)galT</jats:italic>-negative genotype may play a role in the development of gastric cancer.</jats:p>
収録刊行物
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- BioMed Research International
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BioMed Research International 2015 1-8, 2015
Wiley
