Overexpression of CD44 Variant 9: A Novel Cancer Stem Cell Marker in Human Cholangiocarcinoma in Relation to Inflammation

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  • Nattawan Suwannakul
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan
  • Ning Ma
    Graduate School of Health Science, Suzuka University of Medical Science, Suzuka, Mie 513-8670, Japan
  • Raynoo Thanan
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
  • Somchai Pinlaor
    Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand
  • Piti Ungarreevittaya
    Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand
  • Kaoru Midorikawa
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan
  • Yusuke Hiraku
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan
  • Shinji Oikawa
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan
  • Shosuke Kawanishi
    Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Mie 513-8670, Japan
  • Mariko Murata
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan

書誌事項

公開日
2018-10-09
資源種別
journal article
権利情報
  • http://creativecommons.org/licenses/by/4.0/
DOI
  • 10.1155/2018/4867234
  • 10.60692/z4r84-a3779
  • 10.60692/yf8g8-1g425
公開者
Wiley

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説明

<jats:p>Various CD44 isoforms are expressed in several cancer stem cells during tumor progression and metastasis. In particular, CD44 variant 9 (CD44v9) is highly expressed in chronic inflammation-induced cancer. We investigated the expression of CD44v9 and assessed whether CD44v9 is a selective biomarker of human cholangiocarcinoma (CCA). The expression profile of CD44v9 was evaluated in human liver fluke<jats:italic>Opisthorchis viverrini</jats:italic>-related CCA (OV-CCA) tissues, human CCA (independent of OV infection, non-OV-CCA) tissues, and normal liver tissues. CD44v9 overexpression was detected by immunohistochemistry (IHC) in CCA tissues. There was a higher level of CD44v9 expression and IHC score in OV-CCA tissues than in non-OV-CCA tissues, and there was no CD44v9 staining in the bile duct cells of normal liver tissues. In addition, we observed significantly higher expression of inflammation-related markers, such as S100P and COX-2, in OV-CCA tissues compared to that in non-OV and normal liver tissues. Thus, these findings suggest that CD44v9 may be a novel candidate CCA stem cell marker and may be related to inflammation-associated cancer development.</jats:p>

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