Spontaneous, Experimentally Induced, and Transmissible AA Amyloidosis in Japanese Quail (<i>Coturnix japonica</i>)
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- Yumi Nakayama
- Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Fuchu-shi, Tokyo, Japan
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- Junichi Kamiie
- Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan
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- Gen Watanabe
- Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology, Fuchu-shi, Tokyo, Japan
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- Kazuhiko Suzuki
- Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Fuchu-shi, Tokyo, Japan
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- Tomoaki Murakami
- Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Fuchu-shi, Tokyo, Japan
書誌事項
- 公開日
- 2017-08-16
- 資源種別
- journal article
- 権利情報
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- https://journals.sagepub.com/page/policies/text-and-data-mining-license
- DOI
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- 10.1177/0300985817723692
- 公開者
- SAGE Publications
この論文をさがす
説明
<jats:p> The authors describe a spontaneous case of amyloid A (AA) amyloidosis in an adult female Japanese quail ( Coturnix japonica). The bird developed AA amyloidosis secondary to chronic peritonitis caused by a Gram-negative bacillus infection. Mild amyloid deposition was also identified in the intestinal tract of apparently healthy adult individuals, suggesting that quail may develop intestinal amyloidosis with age. Based on these observations, it was hypothesized that quail can develop AA amyloidosis following inflammatory stimulation with lipopolysaccharide (LPS). Therefore, adult quail were repeatedly injected with LPS and the development of AA amyloidosis was confirmed. The amyloid deposition in this model increased when quail amyloid was intravenously injected as an amyloid-enhancing factor. The experiments were repeated with young quail, but amyloid deposits were not observed following LPS injections. However, AA amyloidosis did develop when quail amyloid was injected in addition to LPS. These results indicated that adult quail develop AA amyloidosis after inflammatory stimulation with LPS. Furthermore, quail AA amyloidosis was shown to have transmissibility regardless of age. Interestingly, the authors found that administration of chicken amyloid fibrils also induced AA amyloidosis in young quail. This is the first report of cross-species transmission of avian AA amyloidosis. </jats:p>
収録刊行物
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- Veterinary Pathology
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Veterinary Pathology 54 (6), 912-921, 2017-08-16
SAGE Publications