Preparation of Au/silica/poly(ethylene glycol) nanoparticle colloid solution and its use in x-ray imaging process

DOI Web Site 被引用文献5件 参考文献27件 オープンアクセス
  • Yoshio Kobayashi
    Department of Biomolecular Functional EngineeringCollege of Engineering, Ibaraki University, 4-12-1 Naka-narusawa-cho, Hitachi, Ibaraki, 316-8511, Japan
  • Ryoko Nagasu
    Department of Biomolecular Functional EngineeringCollege of Engineering, Ibaraki University, 4-12-1 Naka-narusawa-cho, Hitachi, Ibaraki, 316-8511, Japan
  • Tomohiko Nakagawa
    Graduate School of MedicineTohoku University, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan
  • Yohsuke Kubota
    Graduate School of MedicineTohoku University, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan
  • Kohsuke Gonda
    Graduate School of MedicineTohoku University, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan
  • Noriaki Ohuchi
    Graduate School of MedicineTohoku University, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan

書誌事項

公開日
2015-02-27
資源種別
journal article
DOI
  • 10.1179/2055033215y.0000000003
公開者
Informa UK Limited

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説明

In this work, the authors performed X-ray imaging of mice using a colloid solution of Au nanoparticles that are coated with silica and subsequently surface-modified with poly(ethylene glycol) (PEG) (Au/SiO2/PEG). The silica-coating for Au nanoparticles and the amination for silica-coated particles were simultaneously performed in the presence of the Au nanoparticles, which were prepared by reducing Au ions (III) with sodium citrate in water at 80°C and by surface-modifying the Au nanoparticles with (3-aminopropyl)-trimethoxysilane (APMS), by a sol–gel process using tetraethylorthosilicate (TEOS), (3-aminopropyl)-triethoxysilane, water and sodium hydroxide (Au/SiO2-NH2). The surface modification of Au/SiO2-NH2 particles with PEG was performed by simply adding PEG with a functional group that reacts with an amino group to the Au/SiO2-NH2 particle colloid solution. A computed tomography value of the Au/SiO2/PEG colloid solution with an Au concentration of 0.129M was as high as 895 ± 8 HU. Mouse tissues were ...

収録刊行物

  • Nanocomposites

    Nanocomposites 1 (2), 83-88, 2015-02-27

    Informa UK Limited

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