JAK2V617F+ myeloproliferative neoplasm clones evoke paracrine DNA damage to adjacent normal cells through secretion of lipocalin-2

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  • Yuki Kagoya
    Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; and
  • Akihide Yoshimi
    Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; and
  • Takako Tsuruta-Kishino
    Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; and
  • Shunya Arai
    Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; and
  • Takashi Satoh
    Laboratory of Host Defense, World Premier International Research Center Initiative, Immunology Frontier Research Center, and
  • Shizuo Akira
    Laboratory of Host Defense, World Premier International Research Center Initiative, Immunology Frontier Research Center, and
  • Mineo Kurokawa
    Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; and

書誌事項

公開日
2014-11-06
資源種別
journal article
DOI
  • 10.1182/blood-2014-04-570572
公開者
American Society of Hematology

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説明

<jats:title>Key Points</jats:title> <jats:p>JAK2V617F+ MPN clones induce paracrine DNA damage into coexisting normal clones through secretion of lipocalin-2. Lipocalin-2 suppresses normal hematopoiesis via p53 pathway activation and gives relative growth advantage to MPN clones.</jats:p>

収録刊行物

  • Blood

    Blood 124 (19), 2996-3006, 2014-11-06

    American Society of Hematology

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