書誌事項
- 公開日
- 2009-12-22
- 資源種別
- journal article
- DOI
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- 10.3109/03602530903492020
- 公開者
- Informa UK Limited
この論文をさがす
説明
Small hepatocytes (SHs) are "committed progenitor cells" that can further differentiate into mature hepatocytes (MHs). SHs can proliferate to form colonies, and the maturation of SHs occurs with the alteration of the cell shape from small and flat to large and rising/piled-up. The hepatic organoids consisting of rising/piled-up cells possess highly differentiated functions like those of MHs and anastomosing networks of bile canaliculi (BC) are developed. The cells can make bile, secrete it into BC, and the bile can be carried without leaking. Thus, the organoids consist of polarized hepatocytes and possess biochemical and physiological functions as hepatic tissue.
収録刊行物
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- Drug Metabolism Reviews
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Drug Metabolism Reviews 42 (3), 472-481, 2009-12-22
Informa UK Limited
