Genomic Characterization of β-Glucuronidase–Positive<i>Escherichia coli</i>O157:H7 Producing Stx2a
書誌事項
- 公開日
- 2018-12
- 資源種別
- journal article
- DOI
-
- 10.3201/eid2412.180404
- 公開者
- Centers for Disease Control and Prevention (CDC)
この論文をさがす
説明
Among Shiga toxin (Stx)-producing Escherichia coli (STEC) O157:H7 strains, those producing Stx2a cause more severe diseases. Atypical STEC O157:H7 strains showing a β-glucuronidase-positive phenotype (GP STEC O157:H7) have rarely been isolated from humans, mostly from persons with asymptomatic or mild infections; Stx2a-producing strains have not been reported. We isolated, from a patient with bloody diarrhea, a GP STEC O157:H7 strain (PV15-279) that produces Stx2a in addition to Stx1a and Stx2c. Genomic comparison with other STEC O157 strains revealed that PV15-279 recently emerged from the stx1a/stx2c-positive GP STEC O157:H7 clone circulating in Japan. Major virulence genes are shared between typical (β-glucuronidase-negative) and GP STEC O157:H7 strains, and the Stx2-producing ability of PV15-279 is comparable to that of typical STEC O157:H7 strains; therefore, PV15-279 presents a virulence potential similar to that of typical STEC O157:H7. This study reveals the importance of GP O157:H7 as a source of highly pathogenic STEC clones.
収録刊行物
-
- Emerging Infectious Diseases
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Emerging Infectious Diseases 24 (12), 2219-2227, 2018-12
Centers for Disease Control and Prevention (CDC)
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キーワード
- Mitomycin
- Infectious and parasitic diseases
- RC109-216
- Escherichia coli O157
- Polymorphism, Single Nucleotide
- Shiga Toxin 2
- Escherichia coli
- Type III Secretion Systems
- bacteria
- genome
- Escherichia coli Infections
- Phylogeny
- Glucuronidase
- Virulence
- Research
- R
- Computational Biology
- Genomics
- Stx2a
- Shiga toxin
- GP STEC O157:H7
- DNA Transposable Elements
- Medicine
- Genome, Bacterial
詳細情報 詳細情報について
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- CRID
- 1360004239345912960
-
- ISSN
- 10806059
- 10806040
-
- PubMed
- 30457544
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- 資料種別
- journal article
-
- データソース種別
-
- Crossref
- KAKEN
- OpenAIRE
