Biochemical aspects of bacterial strategies for handling the incomplete translation processes
書誌事項
- 公開日
- 2014-04-10
- 資源種別
- journal article
- DOI
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- 10.3389/fmicb.2014.00170
- 公開者
- Frontiers Media SA
説明
During protein synthesis in cells, translating ribosomes may encounter abnormal situations that lead to retention of immature peptidyl-tRNA on the ribosome due to failure of suitable termination processes. Bacterial cells handle such situations by employing three systems that rescue the stalled translation machinery. The transfer messenger RNA/small protein B (tmRNA/SmpB) system, also called the trans-translation system, rescues stalled ribosomes by initiating template switching from the incomplete mRNA to the short open reading frame of tmRNA, leading to the production of a protein containing a C-terminal tag that renders it susceptible to proteolysis. The ArfA/RF2 and ArfB systems rescue stalled ribosomes directly by hydrolyzing the immature peptidyl-tRNA remaining on the ribosome. Here, the biochemical aspects of these systems, as clarified by recent studies, are reviewed.
収録刊行物
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- Frontiers in Microbiology
-
Frontiers in Microbiology 5 2014-04-10
Frontiers Media SA
