Reactive Oxygen and Nitrogen Species Regulate Key Metabolic, Anabolic, and Catabolic Pathways in Skeletal Muscle
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- Roland Nemes
- Faculty of Sports and Health Studies, Hosei University, Tokyo 194-0298, Japan
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- Erika Koltai
- Research Institute of Sport Science, University of Physical Education, Alkotas u. 44, H-1123 Budapest, Hungary
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- Albert W. Taylor
- Faculty of Health Sciences, The University of Western Ontario, London, ON N6G 1H1, Canada
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- Katsuhiko Suzuki
- Faculty of Sport Sciences, Waseda University, Saitama 359-1192, Japan
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- Ferenc Gyori
- Institute of Sport Science, University of Szeged, H-6726 Szeged, Hungary
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- Zsolt Radak
- Research Institute of Sport Science, University of Physical Education, Alkotas u. 44, H-1123 Budapest, Hungary
書誌事項
- 公開日
- 2018-07-05
- 資源種別
- journal article
- 権利情報
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- https://creativecommons.org/licenses/by/4.0/
- DOI
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- 10.3390/antiox7070085
- 公開者
- MDPI AG
説明
<jats:p>Reactive oxygen and nitrogen species (RONS) are important cellular regulators of key physiological processes in skeletal muscle. In this review, we explain how RONS regulate muscle contraction and signaling, and why they are important for membrane remodeling, protein turnover, gene expression, and epigenetic adaptation. We discuss how RONS regulate carbohydrate uptake and metabolism of skeletal muscle, and how they indirectly regulate fat metabolism through silent mating type information regulation 2 homolog 3 (SIRT3). RONS are causative/associative signaling molecules, which cause sarcopenia or muscle hypertrophy. Regular exercise influences redox biology, metabolism, and anabolic/catabolic pathways in skeletal muscle in an intensity dependent manner.</jats:p>
収録刊行物
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- Antioxidants
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Antioxidants 7 (7), 85-, 2018-07-05
MDPI AG
