Altered Gene Expression of RNF34 and PACAP Possibly Involved in Mechanism of Exercise-Induced Analgesia for Neuropathic Pain in Rats
-
- Shintaro Yamaoka
- Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon 791-0295, Ehime, Japan
-
- Yusuke Oshima
- Translational Research Center, Ehime University Hospital, Shitsukawa, Toon 791-0295, Ehime, Japan
-
- Hideki Horiuchi
- Ozu Municipal Hospital, Nishiozu, Ozu 795-8501, Ehime, Japan
-
- Tadao Morino
- Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon 791-0295, Ehime, Japan
-
- Masayuki Hino
- Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon 791-0295, Ehime, Japan
-
- Hiromasa Miura
- Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon 791-0295, Ehime, Japan
-
- Tadanori Ogata
- Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon 791-0295, Ehime, Japan
書誌事項
- 公開日
- 2017-09-13
- 資源種別
- journal article
- 権利情報
-
- https://creativecommons.org/licenses/by/4.0/
- DOI
-
- 10.3390/ijms18091962
- 公開者
- MDPI AG
説明
<jats:p>Despite the availability of several modalities of treatment, including surgery, pharmacological agents, and nerve blocks, neuropathic pain is often unresponsive and sometimes progresses to intractable chronic pain. Although exercise therapy is a candidate for treatment of neuropathic pain, the mechanism underlying its efficacy has not been elucidated. To clarify the molecular mechanism for pain relief induced by exercise, we measured Rnf34 and Pacap mRNA levels in the spinal cord dorsal horn of SNL rats, a model of neuropathic pain. SNL model rats exhibited stable mechanical hyperalgesia for at least 6 weeks. When the rats were forced to exercise on a treadmill, mechanical and thermal hyperalgesia were significantly ameliorated compared with the non-exercise group. Accordingly, gene expression level of Rnf34 and Pacap were also significantly altered in the time course analysis after surgery. These results suggest that exercise therapy possibly involves pain relief in SNL rats by suppressing Rnf34 and Pacap expression in the spinal cord.</jats:p>
収録刊行物
-
- International Journal of Molecular Sciences
-
International Journal of Molecular Sciences 18 (9), 1962-, 2017-09-13
MDPI AG
- Tweet
キーワード
- Spinal Cord Dorsal Horn
- Article
- Rats
- Disease Models, Animal
- Spinal Nerves
- neuropathic pain; exercise therapy; SNL model; LMD; RNA sequence; RNF34; PACAP
- Gene Expression Regulation
- Spinal Cord
- Physical Conditioning, Animal
- Exercise Test
- Animals
- Neuralgia
- Pain Management
- Pituitary Adenylate Cyclase-Activating Polypeptide
- Female
- RNA, Messenger
- Analgesia
- Carrier Proteins
- Spinal Cord Injuries
詳細情報 詳細情報について
-
- CRID
- 1360004239493974912
-
- ISSN
- 14220067
-
- PubMed
- 28902127
-
- 資料種別
- journal article
-
- データソース種別
-
- Crossref
- KAKEN
- OpenAIRE
