Invasion-Related Factors as Potential Diagnostic and Therapeutic Targets in Oral Squamous Cell Carcinoma—A Review
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- Samadarani Siriwardena
- Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya 20400, Sri Lanka
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- Takaaki Tsunematsu
- Department of Pathology and Laboratory Medicine, Tokushima University Graduate School of Biomedical Sciences, Tokushima 770-8503, Japan
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- Guangying Qi
- Department of Pathology and Physiopathology, Guilin Medical University, Guilin 541004, China
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- Naozumi Ishimaru
- Department of Oral Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima 770-8504, Japan
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- Yasusei Kudo
- Department of Oral Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima 770-8504, Japan
書誌事項
- 公開日
- 2018-05-14
- 資源種別
- journal article
- 権利情報
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- https://creativecommons.org/licenses/by/4.0/
- DOI
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- 10.3390/ijms19051462
- 公開者
- MDPI AG
説明
<jats:p>It is well recognized that the presence of cervical lymph node metastasis is the most important prognostic factor in oral squamous cell carcinoma (OSCC). In solid epithelial cancer, the first step during the process of metastasis is the invasion of cancer cells into the underlying stroma, breaching the basement membrane (BM)—the natural barrier between epithelium and the underlying extracellular matrix (ECM). The ability to invade and metastasize is a key hallmark of cancer progression, and the most complicated and least understood. These topics continue to be very active fields of cancer research. A number of processes, factors, and signaling pathways are involved in regulating invasion and metastasis. However, appropriate clinical trials for anti-cancer drugs targeting the invasion of OSCC are incomplete. In this review, we summarize the recent progress on invasion-related factors and emerging molecular determinants which can be used as potential for diagnostic and therapeutic targets in OSCC.</jats:p>
収録刊行物
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- International Journal of Molecular Sciences
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International Journal of Molecular Sciences 19 (5), 1462-, 2018-05-14
MDPI AG
- Tweet
キーワード
- Epithelial-Mesenchymal Transition
- 610
- Review
- epithelial mesenchymal transition (EMT)
- Biomarkers, Tumor
- Cell Adhesion
- Tumor Microenvironment
- metastasis
- tumor microenvironment
- cell signaling
- Animals
- Humans
- Neoplasm Invasiveness
- microRNA
- cell adhesion
- invasion
- oral squamous cell carcinoma
- Gene Expression Regulation, Neoplastic
- MicroRNAs
- Carcinoma, Squamous Cell
- Mouth Neoplasms
- Signal Transduction
詳細情報 詳細情報について
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- CRID
- 1360004239494778112
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- ISSN
- 14220067
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- PubMed
- 29758011
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- 資料種別
- journal article
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- データソース種別
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- Crossref
- KAKEN
- OpenAIRE
