Cell Therapy Using Adipose-Derived Stem Cells for Chronic Liver Injury in Mice
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- Kazuo Ohashi
- Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan
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- Yoshinori Matsubara
- R&D Center, Olympus Corporation, Hachioji, Tokyo, Japan
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- Kohei Tatsumi
- Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan
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- Ayako Kohori
- R&D Center, Olympus Corporation, Hachioji, Tokyo, Japan
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- Rie Utoh
- Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan
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- Hiroshi Kakidachi
- R&D Center, Olympus Corporation, Hachioji, Tokyo, Japan
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- Akihiro Horii
- R&D Center, Olympus Corporation, Hachioji, Tokyo, Japan
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- Masahiro Tsutsumi
- Department of Pathology, Saiseikai Chuwa Hospital, Sakurai, Nara, Japan
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- Teruo Okano
- Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan
Description
The present study investigated whether transplantation of autologous adipose-derived stem cells (ASCs) administered into the systemic circulation of a mouse with chronic liver injury provides therapeutic efficacy in the absence of any undesirable side effects. The ASCs used were isolated from mice with the same genetic background as the recipient mice and expanded in vitro. For the induction of chronic liver injury, mice were repetitively administered twice a week with CCl
Journal
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- Cell Medicine
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Cell Medicine 3 (1-3), 113-119, 2012-01
SAGE Publications
