Salmon cartilage proteoglycan attenuates allergic responses in mouse model of papain‑induced respiratory inflammation
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- Hisaya Ono
- Laboratory of Zoonoses, Kitasato University School of Veterinary Medicine, Towada, Aomori 034‑8628, Japan
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- Sayuri Yoshimura
- Tohoku Women's College, Hirosaki, Aomori 036‑8503, Japan
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- Shouhei Hirose
- Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036‑8562, Japan
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- Kouji Narita
- Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036‑8562, Japan
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- Makoto Tsuboi
- Research and Development Department, Ichimaru Pharcos Co., Ltd., Motosu, Gifu 501‑0475, Japan
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- Krisana Asano
- Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036‑8562, Japan
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- Akio Nakane
- Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036‑8562, Japan
書誌事項
- 公開日
- 2018-08-08
- 資源種別
- journal article
- DOI
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- 10.3892/mmr.2018.9364
- 公開者
- Spandidos Publications
この論文をさがす
説明
Proteoglycan (PG) is a complex glycohydrate, which is widely distributed in the extracellular matrix. It has been reported that daily oral administration of PG (extracted from salmon nasal cartilage) modulates the severity of proinflammatory cytokine responses in mouse experimental colitis, autoimmune encephalomyelitis, collagen‑induced arthritis and obesity‑induced inflammation. The present study investigated the effect of salmon nasal cartilage PG on allergic responses using a mouse model of papain‑induced respiratory inflammation. Low titers of immunoglobulin E were identified in the sera of the PG‑administered mice. Oral administration of PG attenuated eosinophil infiltration in the lung. In the acute model of papain‑induced allergic inflammation, PG‑administered mice exhibited low titers of epithelium‑derived and T helper 2‑associated cytokines. The results of the present study demonstrated that salmon cartilage PG has an immunomodulatory effect on intranasally delivered papain. These results suggest a potential role for PG as a prophylactic agent which may attenuate allergic respiratory inflammation.
収録刊行物
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- Molecular Medicine Reports
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Molecular Medicine Reports 2018-08-08
Spandidos Publications
