書誌事項
- 公開日
- 2020-02-18
- 資源種別
- journal article
- DOI
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- 10.1101/cshperspect.a036715
- 公開者
- Cold Spring Harbor Laboratory
説明
Cardiac neural crest (CNC) cells are pluripotent cells derived from the dorsal neural tube that migrate and contribute to the remodeling of pharyngeal arch arteries and septation of the cardiac outflow tract (OFT). Numerous molecular cascades regulate the induction, specification, delamination, and migration of the CNC. Extensive analyses of the CNC ranging from chick ablation models to molecular biology studies have explored the mechanisms of heart development and disease, particularly involving the OFT and aortic arch (AA) system. Recent studies focus more on reciprocal signaling between the CNC and cells originated from the second heart field (SHF), which are essential for the development of the OFT myocardium, providing new insights into the molecular mechanisms underlying congenital heart diseases (CHDs) and some human syndromes.
収録刊行物
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- Cold Spring Harbor Perspectives in Biology
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Cold Spring Harbor Perspectives in Biology 13 (1), a036715-, 2020-02-18
Cold Spring Harbor Laboratory