<i>IL‐28B</i> variant as a predictor in patients with advanced hepatocellular carcinoma treated with hepatic arterial infusion chemotherapy
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- Takeshi Terashima
- Department of Gastroenterology Kanazawa University Hospital Kanazawa Ishikawa Japan
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- Masao Honda
- Department of Gastroenterology Kanazawa University Hospital Kanazawa Ishikawa Japan
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- Tadashi Toyama
- Innovative Clinical Research Center Kanazawa University Kanazawa Ishikawa Japan
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- Tetsuro Shimakami
- Department of Gastroenterology Kanazawa University Hospital Kanazawa Ishikawa Japan
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- Ryogo Shimizu
- Department of Gastroenterology Kanazawa University Hospital Kanazawa Ishikawa Japan
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- Hajime Takatori
- Department of Gastroenterology Kanazawa University Hospital Kanazawa Ishikawa Japan
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- Kuniaki Arai
- Department of Gastroenterology Kanazawa University Hospital Kanazawa Ishikawa Japan
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- Kazunori Kawaguchi
- Department of Gastroenterology Kanazawa University Hospital Kanazawa Ishikawa Japan
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- Kazuya Kitamura
- Department of Gastroenterology Kanazawa University Hospital Kanazawa Ishikawa Japan
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- Taro Yamashita
- Department of Gastroenterology Kanazawa University Hospital Kanazawa Ishikawa Japan
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- Yoshio Sakai
- Department of Gastroenterology Kanazawa University Hospital Kanazawa Ishikawa Japan
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- Tatsuya Yamashita
- Department of Gastroenterology Kanazawa University Hospital Kanazawa Ishikawa Japan
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- Eishiro Mizukoshi
- Department of Gastroenterology Kanazawa University Hospital Kanazawa Ishikawa Japan
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- Shuichi Kaneko
- Department of Gastroenterology Kanazawa University Hospital Kanazawa Ishikawa Japan
Abstract
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background and Aim</jats:title><jats:p>Single‐nucleotide polymorphisms (SNPs) of the interleukin‐28B (<jats:italic>IL‐28B</jats:italic>) gene are associated with the effectiveness of interferon therapy for chronic hepatitis C infection. Whether the <jats:italic>IL‐28B</jats:italic> genotype affects the course of treatment and the outcomes of patients with advanced hepatocellular carcinoma (HCC) is unknown.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We detected the <jats:italic>IL‐28B</jats:italic> SNP (rs8099917) using TaqMan PreDesigned SNP Genotyping Assays to assess the effects of the <jats:italic>IL‐28B</jats:italic> genotype on treatment efficacy and prognosis of patients with advanced HCC treated with hepatic arterial infusion chemotherapy (HAIC) between September 2003 and January 2015.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The study included 154 patients who received HAIC to treat advanced HCC, among which 27 (17.5%) had the minor genotype, <jats:italic>IL‐28B</jats:italic> rs8099917 TG or GG, and the others had the major genotype, <jats:italic>IL‐28B</jats:italic> rs8099917 TT. The objective response rates of patients with the minor or major genotype were 51.9% and 29.1% (<jats:italic>P</jats:italic> = 0.022), respectively. Multivariate analysis revealed that the minor genotype remained associated with the response to HAIC (odds ratio, 2.620; <jats:italic>P</jats:italic> = 0.026). The median overall survival of patients with major or minor genotypes was 14.1 and 16.9 months, respectively, and the overall survival of patients with the major genotype was significantly shorter than that of patients with the minor genotype (<jats:italic>P</jats:italic> = 0.027). Multivariate analysis revealed that the major genotype was an independent, unfavorable prognostic factor (hazard ratio, 1.720; <jats:italic>P</jats:italic> = 0.024). Consistent results were obtained in selected populations after propensity score matching analysis.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The <jats:italic>IL‐28B</jats:italic> SNP (rs8099917) will serve as a useful predictor of the outcomes of patients with advanced HCC treated with HAIC.</jats:p></jats:sec>
Journal
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- Journal of Gastroenterology and Hepatology
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Journal of Gastroenterology and Hepatology 35 (10), 1813-1820, 2020-04
Wiley
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Keywords
Details 詳細情報について
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- CRID
- 1360005520782151552
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- ISSN
- 14401746
- 08159319
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- Data Source
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- Crossref
- KAKEN