Diurnal variation of salivary oxidative stress marker 8-hydroxyguanine

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<jats:title>Abstract</jats:title><jats:sec> <jats:title>Introduction</jats:title> <jats:p>Oxidative stress is a risk factor for life-style related diseases, including cancer. We recently reported that the oxidative stress marker 8-hydroxyguanine (8-OHGua) can be measured in saliva non-invasively. Understanding the diurnal pattern of salivary 8-OHGua levels is crucial for evaluating the oxidative stress. In this study, we analyzed the diurnal variation of salivary 8-OHGua levels.</jats:p> </jats:sec><jats:sec> <jats:title>Findings</jats:title> <jats:p>The salivary 8-OHGua levels were relatively stable in the daytime (10:00–22:00). The daytime 8-OHGua levels seemed to represent the individual oxidative stress status. The average amount and the variation of the salivary 8-OHGua levels immediately after awakening were higher than those of the daytime levels.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>The 8-OHGua levels in saliva exhibited diurnal variation. The levels were higher at the time of awakening. At this point, the daytime levels of salivary 8-OHGua may be appropriate for evaluating the individual oxidative stress status. Further study is needed for understanding and utilizing the 8-OHGua levels at the time of awakening.</jats:p> </jats:sec>

Journal

  • Genes and Environment

    Genes and Environment 41 (1), 20-, 2019-12

    Springer Science and Business Media LLC

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