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- Nikhil R Bhagwat
- Howard Hughes Medical Institute, University of California Davis, Davis, United States
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- Shannon N Owens
- Department of Microbiology & Molecular Genetics, University of California Davis, Davis, United States
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- Masaru Ito
- Howard Hughes Medical Institute, University of California Davis, Davis, United States
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- Jay V Boinapalli
- Department of Microbiology & Molecular Genetics, University of California Davis, Davis, United States
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- Philip Poa
- Department of Microbiology & Molecular Genetics, University of California Davis, Davis, United States
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- Alexander Ditzel
- Department of Microbiology & Molecular Genetics, University of California Davis, Davis, United States
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- Srujan Kopparapu
- Department of Microbiology & Molecular Genetics, University of California Davis, Davis, United States
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- Meghan Mahalawat
- Department of Microbiology & Molecular Genetics, University of California Davis, Davis, United States
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- Owen Richard Davies
- Institute for Cell and Molecular Biosciences, University of Newcastle, Newcastle upon Tyne, United Kingdom
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- Sean R Collins
- Department of Microbiology & Molecular Genetics, University of California Davis, Davis, United States
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- Jeffrey R Johnson
- Department of Cellular & Molecular Pharmacology, University of California San Francisco, San Francisco, United States
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- Nevan J Krogan
- Department of Cellular & Molecular Pharmacology, University of California San Francisco, San Francisco, United States
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- Neil Hunter
- Howard Hughes Medical Institute, University of California Davis, Davis, United States
説明
<jats:p>Protein modification by SUMO helps orchestrate the elaborate events of meiosis to faithfully produce haploid gametes. To date, only a handful of meiotic SUMO targets have been identified. Here, we delineate a multidimensional SUMO-modified meiotic proteome in budding yeast, identifying 2747 conjugation sites in 775 targets, and defining their relative levels and dynamics. Modified sites cluster in disordered regions and only a minority match consensus motifs. Target identities and modification dynamics imply that SUMOylation regulates all levels of chromosome organization and each step of meiotic prophase I. Execution-point analysis confirms these inferences, revealing functions for SUMO in S-phase, the initiation of recombination, chromosome synapsis and crossing over. K15-linked SUMO chains become prominent as chromosomes synapse and recombine, consistent with roles in these processes. SUMO also modifies ubiquitin, forming hybrid oligomers with potential to modulate ubiquitin signaling. We conclude that SUMO plays diverse and unanticipated roles in regulating meiotic chromosome metabolism.</jats:p>
収録刊行物
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- eLife
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eLife 10 2021-01-27
eLife Sciences Publications, Ltd