Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behçet's disease susceptibility

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We analyzed 1,900 Turkish Behçet's disease cases and 1,779 controls genotyped with the Immunochip. The most significantly associated SNP was rs1050502, a tag SNP for HLA-B*51. In the Turkish discovery set, we identified three new risk loci, IL1A-IL1B, IRF8, and CEBPB-PTPN1, with genome-wide significance (P5 × 10

Journal

  • Nature Genetics

    Nature Genetics 49 (3), 438-443, 2017-02-06

    Springer Science and Business Media LLC

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