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Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling
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Description
The nuclear receptor peroxisome proliferator-activated receptor (PPAR)γ has been implicated in the pathogenesis of various human diseases including fatty liver. Although nuclear translocation of PPARγ plays an important role in PPARγ signaling, details of the translocation mechanisms have not been elucidated. Here we demonstrate that PPARγ2 translocates to the nucleus and activates signal transduction through H
Journal
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- Free Radical Biology and Medicine
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Free Radical Biology and Medicine 156 45-56, 2020-08
Elsevier BV