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- A Tran‐Dinh
- INSERM UMR698 Paris France
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- D Diallo
- INSERM UMR698 Paris France
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- S Delbosc
- INSERM UMR698 Paris France
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- L Maria Varela‐Perez
- INSERM UMR698 Paris France
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- QB Dang
- INSERM UMR698 Paris France
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- B Lapergue
- INSERM UMR698 Paris France
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- E Burillo
- Universidad Autonoma de Madrid Fundacion Jimenez Diaz Madrid Spain
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- JB Michel
- INSERM UMR698 Paris France
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- A Levoye
- INSERM UMR698 Paris France
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- JL Martin‐Ventura
- Universidad Autonoma de Madrid Fundacion Jimenez Diaz Madrid Spain
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- O Meilhac
- INSERM UMR698 Paris France
説明
<jats:p>High‐density lipoproteins (<jats:styled-content style="fixed-case">HDLs</jats:styled-content>) represent a family of particles characterized by the presence of apolipoprotein<jats:styled-content style="fixed-case">A</jats:styled-content>‐<jats:styled-content style="fixed-case">I</jats:styled-content>(apo<jats:styled-content style="fixed-case">A</jats:styled-content>‐<jats:styled-content style="fixed-case">I</jats:styled-content>) and by their ability to transport cholesterol from peripheral tissues back to the liver. In addition to this function,<jats:styled-content style="fixed-case">HDLs</jats:styled-content>display pleiotropic effects including antioxidant, anti‐apoptotic, anti‐inflammatory, anti‐thrombotic or anti‐proteolytic properties that account for their protective action on endothelial cells. Vasodilatation via production of nitric oxide is also a hallmark of<jats:styled-content style="fixed-case">HDL</jats:styled-content>action on endothelial cells. Endothelial cells express receptors for apo<jats:styled-content style="fixed-case">A</jats:styled-content>‐<jats:styled-content style="fixed-case">I</jats:styled-content>and<jats:styled-content style="fixed-case">HDLs</jats:styled-content>that mediate intracellular signalling and potentially participate in the internalization of these particles. In this review, we will detail the different effects of<jats:styled-content style="fixed-case">HDLs</jats:styled-content>on the endothelium in normal and pathological conditions with a particular focus on the potential use of<jats:styled-content style="fixed-case">HDL</jats:styled-content>therapy to restore endothelial function and integrity.</jats:p>
収録刊行物
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- British Journal of Pharmacology
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British Journal of Pharmacology 169 (3), 493-511, 2013-05-16
Wiley