Functional role of AMP‐activated protein kinase in the heart during exercise
書誌事項
- 公開日
- 2005-03-11
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1016/j.febslet.2005.02.052
- 公開者
- Wiley
この論文をさがす
説明
<jats:p>AMP‐activated protein kinase (AMPK) plays a critical role in maintaining energy homeostasis and cardiac function during ischemia in the heart. However, the functional role of AMPK in the heart during exercise is unknown. We examined whether acute exercise increases AMPK activity in mouse hearts and determined the significance of these increases by studying transgenic (TG) mice expressing a cardiac‐specific dominant‐negative (inactivating) AMPKα2 subunit. Exercise increased cardiac AMPKα2 activity in the wild type mice but not in TG. We found that inactivation of AMPK did not result in abnormal ATP and glycogen consumption during exercise, cardiac function assessed by heart rhythm telemetry and stress echocardiography, or in maximal exercise capacity.</jats:p>
収録刊行物
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- FEBS Letters
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FEBS Letters 579 (10), 2045-2050, 2005-03-11
Wiley