Structure of Linkage Disequilibrium in Plants

DOI Web Site 9 Citations
  • Sherry A. Flint-Garcia
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695;
  • Jeffry M. Thornsberry
    USDA-ARS, Plant Science Research Unit, Raleigh, North Carolina 27695; Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695;,
  • Edward S. Buckler
    USDA-ARS, Plant Science Research Unit, Raleigh, North Carolina 27695; Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695;,

Description

<jats:p> Future advances in plant genomics will make it possible to scan a genome for polymorphisms associated with qualitative and quantitative traits. Before this potential can be realized, we must understand the nature of linkage disequilibrium (LD) within a genome. LD, the nonrandom association of alleles at different loci, plays an integral role in association mapping, and determines the resolution of an association study. Recently, association mapping has been exploited to dissect quantitative trait loci (QTL). With the exception of maize and Arabidopsis, little research has been conducted on LD in plants. The mating system of the species (selfing versus outcrossing), and phenomena such as population structure and recombination hot spots, can strongly influence patterns of LD. The basic patterns of LD in plants will be better understood as more species are analyzed. </jats:p>

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