Diffusion Tensor Imaging in Autism Spectrum Disorder: A Review
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- Brittany G. Travers
- Waisman Laboratory for Brain Imaging and Behavior University of Wisconsin Madison Wisconsin
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- Nagesh Adluru
- Waisman Laboratory for Brain Imaging and Behavior University of Wisconsin Madison Wisconsin
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- Chad Ennis
- Waisman Laboratory for Brain Imaging and Behavior University of Wisconsin Madison Wisconsin
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- Do P. M. Tromp
- Waisman Laboratory for Brain Imaging and Behavior University of Wisconsin Madison Wisconsin
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- Dan Destiche
- Waisman Laboratory for Brain Imaging and Behavior University of Wisconsin Madison Wisconsin
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- Sam Doran
- Waisman Laboratory for Brain Imaging and Behavior University of Wisconsin Madison Wisconsin
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- Erin D. Bigler
- Department of Psychology Brigham Young University Provo Utah
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- Nicholas Lange
- Departments of Psychiatry and Biostatistics Harvard University Boston Massachusetts
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- Janet E. Lainhart
- Department of Psychiatry and Neuroscience Program University of Utah Salt Lake City Utah
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- Andrew L. Alexander
- Waisman Laboratory for Brain Imaging and Behavior University of Wisconsin Madison Wisconsin
Abstract
<jats:p>White matter tracts of the brain allow neurons and neuronal networks to communicate and function with high efficiency. The aim of this review is to briefly introduce diffusion tensor imaging methods that examine white matter tracts and then to give an overview of the studies that have investigated white matter integrity in the brains of individuals with autism spectrum disorder (<jats:styled-content style="fixed-case">ASD</jats:styled-content>). From the 48 studies we reviewed, persons with <jats:styled-content style="fixed-case">ASD</jats:styled-content> tended to have decreased fractional anisotropy and increased mean diffusivity in white matter tracts spanning many regions of the brain but most consistently in regions such as the corpus callosum, cingulum, and aspects of the temporal lobe. This decrease in fractional anisotropy was often accompanied by increased radial diffusivity. Additionally, the review suggests possible atypical lateralization in some white matter tracts of the brain and a possible atypical developmental trajectory of white matter microstructure in persons with <jats:styled-content style="fixed-case">ASD</jats:styled-content>. Clinical implications and future research directions are discussed. <jats:italic><jats:bold>Autism Res</jats:bold> 2012, 5: 289–313.</jats:italic> © 2012 International Society for Autism Research, Wiley Periodicals, Inc.</jats:p>
Journal
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- Autism Research
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Autism Research 5 (5), 289-313, 2012-07-11
Wiley
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Details 詳細情報について
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- CRID
- 1360011143796164224
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- DOI
- 10.1002/aur.1243
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- ISSN
- 19393806
- 19393792
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- Data Source
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- Crossref