Molecular assessment of surgical-resection margins of gastric cancer by mass-spectrometric imaging
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- Livia S. Eberlin
- Department of Chemistry, Stanford University, Stanford, CA 94305-5080;
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- Robert J. Tibshirani
- Departments of Health Research and Policy and of Statistics, Stanford University, Stanford, CA 94305-4065;
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- Jialing Zhang
- Department of Chemistry, Stanford University, Stanford, CA 94305-5080;
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- Teri A. Longacre
- Department of Pathology, Stanford University, Stanford, CA 94305-5324; and
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- Gerald J. Berry
- Department of Pathology, Stanford University, Stanford, CA 94305-5324; and
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- David B. Bingham
- Department of Pathology, Stanford University, Stanford, CA 94305-5324; and
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- Jeffrey A. Norton
- Department of Surgery, Stanford University, Stanford, CA 94305-5641
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- Richard N. Zare
- Department of Chemistry, Stanford University, Stanford, CA 94305-5080;
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- George A. Poultsides
- Department of Surgery, Stanford University, Stanford, CA 94305-5641
書誌事項
- 公開日
- 2014-02-03
- DOI
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- 10.1073/pnas.1400274111
- 公開者
- Proceedings of the National Academy of Sciences
この論文をさがす
説明
<jats:title>Significance</jats:title><jats:p>Complete resection of a tumor is associated with an improved prognosis for most types of solid malignancies. In gastric-cancer surgery, surgical-margin evaluation is commonly performed intraoperatively by histopathologic evaluation of frozen sections. However, frozen-section results are subjective and can be unreliable in up to 30% of patients undergoing resection of gastrointestinal cancers. We used desorption electrospray ionization mass spectrometric imaging (DESI-MSI) and the statistical method of least absolute shrinkage and selection operator (Lasso) to classify tissue as cancer or normal based on molecular information obtained from tissue and also to select those mass-spectra features most indicative of disease state. The results obtained using margin samples from nine gastric-cancer operations suggest that DESI-MSI/Lasso may be a valuable tool for routine intraoperative assessment of surgical margins during gastric-cancer surgery.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 111 (7), 2436-2441, 2014-02-03
Proceedings of the National Academy of Sciences