Innate lymphoid cells: A new paradigm in immunology

DOI Web Site 26 Citations
  • Gérard Eberl
    Institut Pasteur, Microenvironment and Immunity Unit, 75724 Paris, France.
  • Marco Colonna
    Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • James P. Di Santo
    Institut Pasteur, Innate Immunity Unit, INSERM U668, 75724 Paris, France.
  • Andrew N. J. McKenzie
    Medical Research Council (MRC) Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.

Description

<jats:title>Cells acting at the intersection of immunity</jats:title> <jats:p> For years, scientists divided the immune system into two arms: innate and adaptive. The cell types involved in the two arms differ in specificity and in how quickly they respond to infections. More recently, immunologists discovered a family of immune cells termed “innate lymphoid cells,” which straddle these two arms. Eberl <jats:italic>et al.</jats:italic> review current understanding of innate lymphoid cells. Like innate immune cells, they respond to infection quickly and do not express antigen receptors; however, they secrete a similar suite of inflammatory mediators as T lymphocytes. Better understanding of the processes regulating these cells may allow for their therapeutic manipulation. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaa6566">10.1126/science.aaa6566</jats:related-article> </jats:p>

Journal

  • Science

    Science 348 (6237), aaa6566-, 2015-05-22

    American Association for the Advancement of Science (AAAS)

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