Tumor Formation Dependent on Proteoglycan Biosynthesis

DOI Web Site 被引用文献3件
  • Jeffrey D. Esko
    Department of Biochemistry, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingam, AL 35294.
  • Katherine S. Rostand
    Department of Biochemistry, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingam, AL 35294.
  • Julie L. Weinke
    Department of Biochemistry, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingam, AL 35294.

抄録

<jats:p> The role proteoglycans play in tumor formation was examined by measuring the tumorigenicity of proteoglycan-deficient Chinese hamster ovary cell mutants in nude mice. When 10 <jats:sup>7</jats:sup> cells were injected subcutaneously, mutants with less than about 15% of the wild-type level of proteoglycan synthesis did not produce tumors. Mutants defective in the synthesis of heparan sulfate proteoglycans also did not form tumors, whereas mutants with altered chondroitin sulfate proteoglycans were tumorigenic. Tumors arose from mixtures of wild-type and nontumorigenic mutant cells and contained both cell types, suggesting that wild-type cell proteoglycans enabled mutant cells to survive. The failure of heparan sulfate-deficient mutants to form tumors depended on the ability of the host to mount a B cell-mediated immune reaction. </jats:p>

収録刊行物

  • Science

    Science 241 (4869), 1092-1096, 1988-08-26

    American Association for the Advancement of Science (AAAS)

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