A Promoter Genotype and Oxidative Stress Potentially Link Resistin to Human Insulin Resistance

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書誌事項

公開日
2003-07-01
DOI
  • 10.2337/diabetes.52.7.1611
公開者
American Diabetes Association

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説明

<jats:p>Insulin resistance is a component of type 2 diabetes and often precedes pancreatic β-cell failure. Contributing factors include obesity and a central pattern of fat accumulation with a strong genetic component. The adipocyte secreted hormone resistin has been proposed as a link between the adipocyte and insulin resistance by inhibition of insulin-stimulated glucose uptake and/or blocking adipocyte differentiation. Here we report that the G/G genotype of a single nucleotide polymorphism (SNP) in the promoter of the human resistin gene, −180C&gt;G, had significantly increased basal promoter activity in adipocytes. These data were recapitulated in vivo, where G/G homozygotes had significantly higher resistin mRNA levels in human abdominal subcutaneous fat. A significant interaction was also found between the −180C&gt;G SNP, a marker of oxidative stress (NAD[P]H quinone oxidoreductase mRNA) and homeostasis model assessment of insulin resistance. In addition, resistin mRNA was positively and independently correlated with insulin resistance and hepatic fat as measured by liver X-ray attenuation. These data implicate resistin in the pathophysiology of the human insulin resistance syndrome, an effect mediated by the −180C&gt;G promoter SNP and potentially cellular oxidative stress.</jats:p>

収録刊行物

  • Diabetes

    Diabetes 52 (7), 1611-1618, 2003-07-01

    American Diabetes Association

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