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- Daniel W. Belsky
- Department of Medicine, Duke University School of Medicine, Durham, NC 27710;
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- Avshalom Caspi
- Department of Psychology & Neuroscience, Duke University, Durham, NC 27708;
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- Renate Houts
- Department of Psychology & Neuroscience, Duke University, Durham, NC 27708;
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- Harvey J. Cohen
- Department of Medicine, Duke University School of Medicine, Durham, NC 27710;
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- David L. Corcoran
- Center for Genomic and Computational Biology, Duke University, Durham, NC 27708;
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- Andrea Danese
- Social, Genetic, & Developmental Psychiatry Research Centre, Institute of Psychiatry, Kings College London, London SE5 8AF, United Kingdom;
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- HonaLee Harrington
- Department of Psychology & Neuroscience, Duke University, Durham, NC 27708;
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- Salomon Israel
- Department of Psychology, The Hebrew University of Jerusalem, Jerusalem 91905, Israel;
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- Morgan E. Levine
- Department of Human Genetics, Gonda Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095;
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- Jonathan D. Schaefer
- Department of Psychology & Neuroscience, Duke University, Durham, NC 27708;
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- Karen Sugden
- Department of Psychology & Neuroscience, Duke University, Durham, NC 27708;
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- Ben Williams
- Department of Psychology & Neuroscience, Duke University, Durham, NC 27708;
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- Anatoli I. Yashin
- Social Science Research Institute, Duke University, Durham, NC 27708;
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- Richie Poulton
- Department of Psychology, University of Otago, Dunedin 9016, New Zealand
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- Terrie E. Moffitt
- Department of Psychology & Neuroscience, Duke University, Durham, NC 27708;
抄録
<jats:title>Significance</jats:title> <jats:p>The global population is aging, driving up age-related disease morbidity. Antiaging interventions are needed to reduce the burden of disease and protect population productivity. Young people are the most attractive targets for therapies to extend healthspan (because it is still possible to prevent disease in the young). However, there is skepticism about whether aging processes can be detected in young adults who do not yet have chronic diseases. Our findings indicate that aging processes can be quantified in people still young enough for prevention of age-related disease, opening a new door for antiaging therapies. The science of healthspan extension may be focused on the wrong end of the lifespan; rather than only studying old humans, geroscience should also study the young.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 112 (30), E4104-, 2015-07-06
Proceedings of the National Academy of Sciences