Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies

DOI PDF 2 Citations
  • Geoffrey M. Matthews
    Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia;
  • Parinaz Mehdipour
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy;
  • Leonie A. Cluse
    Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia;
  • Katrina J. Falkenberg
    Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia;
  • Eric Wang
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY;
  • Mareike Roth
    Research Institute of Molecular Pathology, Vienna Biocenter, Vienna, Austria;
  • Fabio Santoro
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy;
  • Eva Vidacs
    Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia;
  • Kym Stanley
    Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia;
  • Colin M. House
    Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia;
  • James R. Rusche
    Repligen Corporation, Waltham, MA;
  • Christopher R. Vakoc
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY;
  • Johannes Zuber
    Research Institute of Molecular Pathology, Vienna Biocenter, Vienna, Austria;
  • Saverio Minucci
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy;
  • Ricky W. Johnstone
    Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia;

Description

<jats:title>Key Points</jats:title> <jats:p>Genetic studies suggest HDAC3-selective suppression may prove useful for treatment of hematological tumors but will not induce apoptosis. Genetic and pharmacological cosuppression of HDAC1 with HDAC2 induces a potent pro-apoptotic response of tumor cells.</jats:p>

Journal

  • Blood

    Blood 126 (21), 2392-2403, 2015-11-19

    American Society of Hematology

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