Six-Month Versus 12-Month Dual Antiplatelet Therapy After Implantation of Drug-Eluting Stents
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- Hyeon-Cheol Gwon
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- Joo-Yong Hahn
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- Kyung Woo Park
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- Young Bin Song
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- In-Ho Chae
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- Do-Sun Lim
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- Kyoo-Rok Han
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- Jin-Ho Choi
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- Seung-Hyuk Choi
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- Hyun-Jae Kang
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- Bon-Kwon Koo
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- Taehoon Ahn
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- Jung-Han Yoon
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- Myung-Ho Jeong
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- Taek-Jong Hong
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- Woo-Young Chung
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- Young-Jin Choi
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- Seung-Ho Hur
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- Hyuck-Moon Kwon
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- Dong-Woon Jeon
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- Byung-Ok Kim
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- Si-Hoon Park
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- Nam-Ho Lee
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- Hui-Kyung Jeon
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- Yangsoo Jang
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
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- Hyo-Soo Kim
- From the Division of Cardiology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (H.-C.G., J.-Y.H., Y.B.S., J.-H.C., S.-H.C.); Cardiovascular Center, Seoul National University Main Hospital, Seoul (K.W.P., H.-J.K., B.-K.K., H.-S.K.); Seoul National University Bundang Hospital, Sungnam (I.-H.C.); Korea University Anam Hospital, Seoul (D.-S.L.); Kangdong Sacred Heart Hospital, Seoul (K.-R.H.); Gachon University Gil Medical Center, Incheon (T.A.);...
Bibliographic Information
- Other Title
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- The Efficacy of Xience/Promus Versus Cypher to Reduce Late Loss After Stenting (EXCELLENT) Randomized, Multicenter Study
Description
<jats:sec> <jats:title>Background—</jats:title> <jats:p>The optimal duration of dual antiplatelet therapy (DAPT) after implantation of drug-eluting coronary stents remains undetermined. We aimed to test whether 6-month DAPT would be noninferior to 12-month DAPT after implantation of drug-eluting stents.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods and Results—</jats:title> <jats:p> We randomly assigned 1443 patients undergoing implantation of drug-eluting stents to receive 6- or 12-month DAPT (in a 1:1 ratio). The primary end point was a target vessel failure, defined as the composite of cardiac death, myocardial infarction, or ischemia-driven target vessel revascularization at 12 months. Rates of target vessel failure at 12 months were 4.8% in the 6-month DAPT group and 4.3% in the 12-month DAPT group (the upper limit of 1-sided 95% confidence interval, 2.4%; <jats:italic>P</jats:italic> =0.001 for noninferiority with a predefined noninferiority margin of 4.0%). Although stent thrombosis tended to occur more frequently in the 6-month DAPT group than in the 12-month group (0.9% versus 0.1%; hazard ratio, 6.02; 95% confidence interval, 0.72–49.96; <jats:italic>P</jats:italic> =0.10), the risk of death or myocardial infarction did not differ in the 2 groups (2.4% versus 1.9%; hazard ratio, 1.21; 95% confidence interval, 0.60–2.47; <jats:italic>P</jats:italic> =0.58). In the prespecified subgroup analysis, target vessel failure occurred more frequently in the 6-month DAPT group than in the 12-month group (hazard ratio, 3.16; 95% confidence interval, 1.42–7.03; <jats:italic>P</jats:italic> =0.005) among diabetic patients. </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p>Six-month DAPT did not increase the risk of target vessel failure at 12 months after implantation of drug-eluting stents compared with 12-month DAPT. However, the noninferiority margin was wide, and the study was underpowered for death or myocardial infarction. Our results need to be confirmed in larger trials.</jats:p> </jats:sec> <jats:sec> <jats:title>Clinical Trial Registration—</jats:title> <jats:p> URL: <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.clinicaltrials.gov">http://www.clinicaltrials.gov</jats:ext-link> . Unique identifier: NCT00698607. </jats:p> </jats:sec>
Journal
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- Circulation
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Circulation 125 (3), 505-513, 2012-01-24
Ovid Technologies (Wolters Kluwer Health)
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Details 詳細情報について
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- CRID
- 1360011144280365568
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- ISSN
- 15244539
- 00097322
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- Data Source
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- Crossref