Association of Knee Injuries With Accelerated Knee Osteoarthritis Progression: Data From the Osteoarthritis Initiative
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- Jeffrey B. Driban
- Tufts Medical Center Boston Massachusetts
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- Charles B. Eaton
- Brown University Pawtucket Rhode Island
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- Grace H. Lo
- Baylor College of Medicine Houston Texas
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- Robert J. Ward
- Tufts Medical Center Boston Massachusetts
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- Bing Lu
- Harvard Medical School Boston Massachusetts
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- Timothy E. McAlindon
- Tufts Medical Center Boston Massachusetts
説明
<jats:sec><jats:title>Objective</jats:title><jats:p>We aimed to evaluate whether a recent knee injury was associated with accelerated knee osteoarthritis (OA) progression.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>In the Osteoarthritis Initiative, we studied participants free of knee OA on their baseline radiographs (Kellgren/Lawrence [K/L] <2). We compared 3 groups as follows: 1) individuals with accelerated progression of knee OA: defined as having at least 1 knee that progressed to end‐stage knee OA (K/L grade 3 or 4) within 48 months, 2) common knee OA progression: at least 1 knee increased in radiographic scoring within 48 months (excluding those defined as accelerated knee OA), and 3) no knee OA: no change in K/L grade in either knee. At baseline, participants were asked if their knees had ever been injured, and at each annual visit they were asked about injuries during the prior 12 months. We used multinomial logistic regressions to determine whether a new knee injury was associated with the outcome of accelerated knee OA or common knee OA progression, after adjusting for age, sex, body mass index, static knee malalignment, and systolic blood pressure.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A knee injury during the total observation period was associated with accelerated knee OA progression (n = 54; odds ratio [OR] 3.14) but not common knee OA progression (n = 187; OR 1.08). Furthermore, a more recent knee injury (within a year of the outcome) was associated with accelerated (OR 8.46) and common knee OA progression (OR 3.12).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Recent knee injuries are associated with accelerated knee OA. Most concerning is that certain injuries may be associated with a rapid cascade toward joint failure in less than 1 year.</jats:p></jats:sec>
収録刊行物
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- Arthritis Care & Research
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Arthritis Care & Research 66 (11), 1673-1679, 2014-10-24
Wiley