Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction
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- Chen Zhang
- State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Ding-xi Road Shanghai 200050 P. R. China
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- Wenbo Bu
- State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Ding-xi Road Shanghai 200050 P. R. China
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- Dalong Ni
- State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Ding-xi Road Shanghai 200050 P. R. China
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- Shenjian Zhang
- Department of Radiology Shanghai Cancer Hospital Fudan University 270 Dong-an Road Shanghai 200032 P. R. China
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- Qing Li
- State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Ding-xi Road Shanghai 200050 P. R. China
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- Zhenwei Yao
- Department of Radiology Huashan Hospital Fudan University 12 Urumqizhong Road Shanghai 200040 P. R. China
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- Jiawen Zhang
- Department of Radiology Huashan Hospital Fudan University 12 Urumqizhong Road Shanghai 200040 P. R. China
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- Heliang Yao
- State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Ding-xi Road Shanghai 200050 P. R. China
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- Zheng Wang
- State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Ding-xi Road Shanghai 200050 P. R. China
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- Jianlin Shi
- State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Ding-xi Road Shanghai 200050 P. R. China
Description
<jats:title>Abstract</jats:title><jats:p>Metallic glasses and cancer theranostics are emerging fields that do not seem to be related to each other. Herein, we report the facile synthesis of amorphous iron nanoparticles (AFeNPs) and their superior physicochemical properties compared to their crystalline counterpart, iron nanocrystals (FeNCs). The AFeNPs can be used for cancer theranostics by inducing a Fenton reaction in the tumor by taking advantage of the mild acidity and the overproduced H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> in a tumor microenvironment: Ionization of the AFeNPs enables on‐demand ferrous ion release in the tumor, and subsequent H<jats:sub>2</jats:sub>O<jats:sub>2</jats:sub> disproportionation leads to efficient <jats:sup>.</jats:sup>OH generation. The endogenous stimuli‐responsive <jats:sup>.</jats:sup>OH generation in the presence AFeNPs enables a highly specific cancer therapy without the need for external energy input.</jats:p>
Journal
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- Angewandte Chemie International Edition
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Angewandte Chemie International Edition 55 (6), 2101-2106, 2016-01-06
Wiley
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Details 詳細情報について
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- CRID
- 1360011144539493120
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- ISSN
- 15213773
- 14337851
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- Data Source
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- Crossref