Serum Prolidase Activity, Oxidant and Antioxidant Status in Nonulcer Dyspepsia and Healthy Volunteers

<jats:p><jats:italic>Helicobacter pylori (H. pylori)</jats:italic>infection is associated with increased oxidative stress and serum prolidase activity (SPA) in many diseases. We aimed to observe SPA and oxidative stress in nonulcer dyspepsia (NUD) infected with and without<jats:italic>H. pylori</jats:italic>among eastern Indians. 106 patients with<jats:italic>H. pylori</jats:italic>positive NUD, 82 patients with<jats:italic>H. pylori</jats:italic>negative NUD, and 50 healthy individuals were selected. SPA, total antioxidant capacity (TAOC), and total oxidant status (TOS) were measured with the use of spectrophotometer and an automated measurement method. SPA, TOS, and oxidative stress index (OSI) were significantly higher in patients with<jats:italic>H. pylori</jats:italic>positive than<jats:italic>H. pylori</jats:italic>negative NUD and healthy individuals (all ), whereas TAOC was significantly lower (). Nonsignificant, increased SPA ( value = 0.6083) and decreased TAOC ( value = 0.1186) were observed in patients with<jats:italic>H. pylori</jats:italic>negative NUD than healthy individuals, while increased TOS and OSI were significant (). Weak, nonsignificant correlations were observed between serum prolidase activity and TAOC, TOS, and OSI in<jats:italic>H. pylori</jats:italic>positive cases. Thus, increased SPA along with increased oxidative stress was observed, which seem to be closely associated with<jats:italic>H. pylori</jats:italic>infection. SPA and oxidative stress seem to be used as biomarkers for<jats:italic>H. pylori</jats:italic>infection in NUD.</jats:p>