Long-Term Blood Pressure Variability, New-Onset Diabetes Mellitus, and New-Onset Chronic Kidney Disease in the Japanese General Population
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- Yuichiro Yano
- From the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y.); Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine (S.F.) and Dialysis Division, University of Miyazaki Hospital (Y.S.), University of Miyazaki, Miyazaki, Japan; Department of Public Health Sciences (H.K.) and Division of Nephrology and Hypertension (H.K.), Loyola Medical Center, Maywood, IL; Department of Cardiology, Pulmonology, and Nephrology, Yamagata...
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- Shouichi Fujimoto
- From the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y.); Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine (S.F.) and Dialysis Division, University of Miyazaki Hospital (Y.S.), University of Miyazaki, Miyazaki, Japan; Department of Public Health Sciences (H.K.) and Division of Nephrology and Hypertension (H.K.), Loyola Medical Center, Maywood, IL; Department of Cardiology, Pulmonology, and Nephrology, Yamagata...
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- Holly Kramer
- From the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y.); Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine (S.F.) and Dialysis Division, University of Miyazaki Hospital (Y.S.), University of Miyazaki, Miyazaki, Japan; Department of Public Health Sciences (H.K.) and Division of Nephrology and Hypertension (H.K.), Loyola Medical Center, Maywood, IL; Department of Cardiology, Pulmonology, and Nephrology, Yamagata...
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- Yuji Sato
- From the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y.); Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine (S.F.) and Dialysis Division, University of Miyazaki Hospital (Y.S.), University of Miyazaki, Miyazaki, Japan; Department of Public Health Sciences (H.K.) and Division of Nephrology and Hypertension (H.K.), Loyola Medical Center, Maywood, IL; Department of Cardiology, Pulmonology, and Nephrology, Yamagata...
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- Tsuneo Konta
- From the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y.); Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine (S.F.) and Dialysis Division, University of Miyazaki Hospital (Y.S.), University of Miyazaki, Miyazaki, Japan; Department of Public Health Sciences (H.K.) and Division of Nephrology and Hypertension (H.K.), Loyola Medical Center, Maywood, IL; Department of Cardiology, Pulmonology, and Nephrology, Yamagata...
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- Kunitoshi Iseki
- From the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y.); Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine (S.F.) and Dialysis Division, University of Miyazaki Hospital (Y.S.), University of Miyazaki, Miyazaki, Japan; Department of Public Health Sciences (H.K.) and Division of Nephrology and Hypertension (H.K.), Loyola Medical Center, Maywood, IL; Department of Cardiology, Pulmonology, and Nephrology, Yamagata...
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- Chiho Iseki
- From the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y.); Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine (S.F.) and Dialysis Division, University of Miyazaki Hospital (Y.S.), University of Miyazaki, Miyazaki, Japan; Department of Public Health Sciences (H.K.) and Division of Nephrology and Hypertension (H.K.), Loyola Medical Center, Maywood, IL; Department of Cardiology, Pulmonology, and Nephrology, Yamagata...
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- Toshiki Moriyama
- From the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y.); Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine (S.F.) and Dialysis Division, University of Miyazaki Hospital (Y.S.), University of Miyazaki, Miyazaki, Japan; Department of Public Health Sciences (H.K.) and Division of Nephrology and Hypertension (H.K.), Loyola Medical Center, Maywood, IL; Department of Cardiology, Pulmonology, and Nephrology, Yamagata...
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- Kunihiro Yamagata
- From the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y.); Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine (S.F.) and Dialysis Division, University of Miyazaki Hospital (Y.S.), University of Miyazaki, Miyazaki, Japan; Department of Public Health Sciences (H.K.) and Division of Nephrology and Hypertension (H.K.), Loyola Medical Center, Maywood, IL; Department of Cardiology, Pulmonology, and Nephrology, Yamagata...
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- Kazuhiko Tsuruya
- From the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y.); Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine (S.F.) and Dialysis Division, University of Miyazaki Hospital (Y.S.), University of Miyazaki, Miyazaki, Japan; Department of Public Health Sciences (H.K.) and Division of Nephrology and Hypertension (H.K.), Loyola Medical Center, Maywood, IL; Department of Cardiology, Pulmonology, and Nephrology, Yamagata...
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- Ichiei Narita
- From the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y.); Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine (S.F.) and Dialysis Division, University of Miyazaki Hospital (Y.S.), University of Miyazaki, Miyazaki, Japan; Department of Public Health Sciences (H.K.) and Division of Nephrology and Hypertension (H.K.), Loyola Medical Center, Maywood, IL; Department of Cardiology, Pulmonology, and Nephrology, Yamagata...
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- Masahide Kondo
- From the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y.); Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine (S.F.) and Dialysis Division, University of Miyazaki Hospital (Y.S.), University of Miyazaki, Miyazaki, Japan; Department of Public Health Sciences (H.K.) and Division of Nephrology and Hypertension (H.K.), Loyola Medical Center, Maywood, IL; Department of Cardiology, Pulmonology, and Nephrology, Yamagata...
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- Kenjiro Kimura
- From the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y.); Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine (S.F.) and Dialysis Division, University of Miyazaki Hospital (Y.S.), University of Miyazaki, Miyazaki, Japan; Department of Public Health Sciences (H.K.) and Division of Nephrology and Hypertension (H.K.), Loyola Medical Center, Maywood, IL; Department of Cardiology, Pulmonology, and Nephrology, Yamagata...
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- Koichi Asahi
- From the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y.); Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine (S.F.) and Dialysis Division, University of Miyazaki Hospital (Y.S.), University of Miyazaki, Miyazaki, Japan; Department of Public Health Sciences (H.K.) and Division of Nephrology and Hypertension (H.K.), Loyola Medical Center, Maywood, IL; Department of Cardiology, Pulmonology, and Nephrology, Yamagata...
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- Issei Kurahashi
- From the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y.); Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine (S.F.) and Dialysis Division, University of Miyazaki Hospital (Y.S.), University of Miyazaki, Miyazaki, Japan; Department of Public Health Sciences (H.K.) and Division of Nephrology and Hypertension (H.K.), Loyola Medical Center, Maywood, IL; Department of Cardiology, Pulmonology, and Nephrology, Yamagata...
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- Yasuo Ohashi
- From the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y.); Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine (S.F.) and Dialysis Division, University of Miyazaki Hospital (Y.S.), University of Miyazaki, Miyazaki, Japan; Department of Public Health Sciences (H.K.) and Division of Nephrology and Hypertension (H.K.), Loyola Medical Center, Maywood, IL; Department of Cardiology, Pulmonology, and Nephrology, Yamagata...
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- Tsuyoshi Watanabe
- From the Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (Y.Y.); Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine (S.F.) and Dialysis Division, University of Miyazaki Hospital (Y.S.), University of Miyazaki, Miyazaki, Japan; Department of Public Health Sciences (H.K.) and Division of Nephrology and Hypertension (H.K.), Loyola Medical Center, Maywood, IL; Department of Cardiology, Pulmonology, and Nephrology, Yamagata...
Description
<jats:p> Whether long-term blood pressure (BP) variability among individuals without diabetes mellitus is associated with new-onset chronic kidney disease (CKD) risk, independently of other BP parameters (eg, mean BP, cumulative exposure to BP) and metabolic profile changes during follow-up, remains uncertain. We used data from a nationwide study of 48 587 Japanese adults aged 40 to 74 years (mean age, 61.7 years; 39% men) without diabetes mellitus or CKD (estimated glomerular filtration rate <60 mL/min per 1.73 m2 or proteinuria by dipstick). BP was measured at baseline and during 3 annual follow-up visits (4 visits). BP variability was defined as standard deviation (SD) and average real variability during the 4 visits. At the year 3 follow-up visit, 6.3% of the population had developed CKD. In multivariable-adjusted logistic regression models, 1 SD increases in SD <jats:sub>SBP</jats:sub> (per 5 mmHg), SD <jats:sub>DBP</jats:sub> (per 3 mmHg), average real variability <jats:sub>SBP</jats:sub> (per 6 mmHg), and average real variability <jats:sub>DBP</jats:sub> (per 4 mmHg) were associated with new-onset CKD (odds ratios [ORs] and 95% confidence intervals, 1.15 [1.11–1.20], 1.08 [1.04–1.12], 1.13 [1.09–1.17], 1.06 [1.02–1.10], respectively; all <jats:italic>P</jats:italic> <0.01) after adjustment for clinical characteristics, and with mean BP from year 0 to year 3. The associations of SD <jats:sub>BP</jats:sub> and average real variability <jats:sub>BP</jats:sub> with CKD remained significant after additional adjustments for metabolic parameter changes during follow-up (ORs, 1.06–1.15; all <jats:italic>P</jats:italic> <0.01). Sensitivity analyses by sex, antihypertensive medication use, and the presence of hypertension showed similar conclusions. Among those in the middle-aged and elderly general population without diabetes mellitus, long-term BP variability during 3 years was associated with new-onset CKD risk, independently of mean or cumulative exposure to BP and metabolic profile changes during follow-up. </jats:p>
Journal
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- Hypertension
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Hypertension 66 (1), 30-36, 2015-07
Ovid Technologies (Wolters Kluwer Health)
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Details 詳細情報について
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- CRID
- 1360011144816604416
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- ISSN
- 15244563
- 0194911X
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- Data Source
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- Crossref