Predicting Coiled Coils from Protein Sequences

DOI Web Site 被引用文献82件
  • Andrei Lupas
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544
  • Marc Van Dyke
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544
  • Jeff Stock
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544

説明

<jats:p>The probability that a residue in a protein is part of a coiled-coil structure was assessed by comparison of its flanking sequences with sequences of known coiled-coil proteins. This method was used to delineate coiled-coil domains in otherwise globular proteins, such as the leucine zipper domains in transcriptional regulators, and to predict regions of discontinuity within coiled-coil structures, such as the hinge region in myosin. More than 200 proteins that probably have coiled-coil domains were identified in GenBank, including α- and β-tubulins, flagellins, G protein β subunits, some bacterial transfer RNA synthetases, and members of the heat shock protein (Hsp70) family.</jats:p>

収録刊行物

  • Science

    Science 252 (5009), 1162-1164, 1991-05-24

    American Association for the Advancement of Science (AAAS)

被引用文献 (82)*注記

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