説明
<jats:p>Multifunctional drugs are those with more than one therapeutic mechanism. Trazodone is a multifunctional drug with dose-dependent pharmacologic actions. That is, it has hypnotic actions at low doses due to blockade of 5-HT<jats:sub>2A</jats:sub>receptors, as well as H<jats:sub>1</jats:sub>histamine receptors and α1 adrenergic receptors. Higher doses recruit the blockade of the serotonin transporter (SERT) and turn trazodone into an antidepressant. Although trazodone has traditionally been used as a low dose hypnotic, a new controlled release formulation that has the potential to improve the tolerability of high doses may provide an opportunity to revisit this multifunctional drug as an antidepressant as well.</jats:p>
収録刊行物
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- CNS Spectrums
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CNS Spectrums 14 (10), 536-546, 2009-10
Cambridge University Press (CUP)
