<i>In vitro</i> antiprotozoal activity of some xanthones isolated from the roots of <i>Andrographis paniculata</i>

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<jats:title>Abstract</jats:title><jats:p>Four xanthones isolated from the roots of <jats:italic>Andrographis paniculata</jats:italic> were tested <jats:italic>in vitro</jats:italic> for antiprotozoal activity against <jats:italic>Trypanosoma brucei brucei</jats:italic>, <jats:italic>Trypanosoma cruzi</jats:italic> and <jats:italic>Leishmania infantum</jats:italic>. Compound TDR13011 (1,2‐dihydroxy‐6,8‐dimethoxy‐xanthone) showed good activity against <jats:italic>T. b. brucei</jats:italic> and <jats:italic>L. infantum</jats:italic> with a 50% inhibitory concentration (IC<jats:sub>50</jats:sub>) of 4.6 µg/ml and 8 µg/ml respectively. Xanthones from the roots of <jats:italic>Andrographis paniculata</jats:italic> exhibited promising anti‐protozoal activity and these compounds could be chemically modified to obtain a more potent product. Copyright © 2008 John Wiley & Sons, Ltd.</jats:p>

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