IL-17 Plays an Important Role in the Development of Experimental Autoimmune Encephalomyelitis

DOI PDF PubMed 被引用文献75件 オープンアクセス
  • Yutaka Komiyama
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
  • Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
  • Taizo Matsuki
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
  • Aya Nambu
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
  • Harumichi Ishigame
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
  • Shigeru Kakuta
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
  • Katsuko Sudo
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
  • Yoichiro Iwakura
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan

説明

<jats:title>Abstract</jats:title><jats:p>IL-17 is a proinflammatory cytokine that activates T cells and other immune cells to produce a variety of cytokines, chemokines, and cell adhesion molecules. This cytokine is augmented in the sera and/or tissues of patients with contact dermatitis, asthma, and rheumatoid arthritis. We previously demonstrated that IL-17 is involved in the development of autoimmune arthritis and contact, delayed, and airway hypersensitivity in mice. As the expression of IL-17 is also augmented in multiple sclerosis, we examined the involvement of this cytokine in these diseases using IL-17−/− murine disease models. We found that the development of experimental autoimmune encephalomyelitis (EAE), the rodent model of multiple sclerosis, was significantly suppressed in IL-17−/− mice; these animals exhibited delayed onset, reduced maximum severity scores, ameliorated histological changes, and early recovery. T cell sensitization against myelin oligodendrocyte glycoprotein was reduced in IL-17−/− mice upon sensitization. The major producer of IL-17 upon treatment with myelin digodendrocyte glycopritein was CD4+ T cells rather than CD8+ T cells, and adoptive transfer of IL-17−/− CD4+ T cells inefficiently induced EAE in recipient mice. Notably, IL-17-producing T cells were increased in IFN-γ−/− cells, while IFN-γ-producing cells were increased in IL-17−/− cells, suggesting that IL-17 and IFN-γ mutually regulate IFN-γ and IL-17 production. These observations indicate that IL-17 rather than IFN-γ plays a crucial role in the development of EAE.</jats:p>

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