(–)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans
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- Hagen Schroeter
- Department of Nutrition, University of California, One Shields Avenue, 3150E Meyer Hall, Davis, CA 95616; Division of Cardiology, Pulmonology, and Vascular Medicine, Heinrich-Heine University, Moorenstrasse 5, 40225 Duesseldorf, Germany; Institute of Biochemistry and Molecular Biology, Heinrich-Heine University, Universitaetsstrasse 1, 40225 Duesseldorf, Germany; Departments of Medicine and Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115; and Analytical and Applied...
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- Christian Heiss
- Department of Nutrition, University of California, One Shields Avenue, 3150E Meyer Hall, Davis, CA 95616; Division of Cardiology, Pulmonology, and Vascular Medicine, Heinrich-Heine University, Moorenstrasse 5, 40225 Duesseldorf, Germany; Institute of Biochemistry and Molecular Biology, Heinrich-Heine University, Universitaetsstrasse 1, 40225 Duesseldorf, Germany; Departments of Medicine and Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115; and Analytical and Applied...
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- Jan Balzer
- Department of Nutrition, University of California, One Shields Avenue, 3150E Meyer Hall, Davis, CA 95616; Division of Cardiology, Pulmonology, and Vascular Medicine, Heinrich-Heine University, Moorenstrasse 5, 40225 Duesseldorf, Germany; Institute of Biochemistry and Molecular Biology, Heinrich-Heine University, Universitaetsstrasse 1, 40225 Duesseldorf, Germany; Departments of Medicine and Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115; and Analytical and Applied...
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- Petra Kleinbongard
- Department of Nutrition, University of California, One Shields Avenue, 3150E Meyer Hall, Davis, CA 95616; Division of Cardiology, Pulmonology, and Vascular Medicine, Heinrich-Heine University, Moorenstrasse 5, 40225 Duesseldorf, Germany; Institute of Biochemistry and Molecular Biology, Heinrich-Heine University, Universitaetsstrasse 1, 40225 Duesseldorf, Germany; Departments of Medicine and Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115; and Analytical and Applied...
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- Carl L. Keen
- Department of Nutrition, University of California, One Shields Avenue, 3150E Meyer Hall, Davis, CA 95616; Division of Cardiology, Pulmonology, and Vascular Medicine, Heinrich-Heine University, Moorenstrasse 5, 40225 Duesseldorf, Germany; Institute of Biochemistry and Molecular Biology, Heinrich-Heine University, Universitaetsstrasse 1, 40225 Duesseldorf, Germany; Departments of Medicine and Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115; and Analytical and Applied...
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- Norman K. Hollenberg
- Department of Nutrition, University of California, One Shields Avenue, 3150E Meyer Hall, Davis, CA 95616; Division of Cardiology, Pulmonology, and Vascular Medicine, Heinrich-Heine University, Moorenstrasse 5, 40225 Duesseldorf, Germany; Institute of Biochemistry and Molecular Biology, Heinrich-Heine University, Universitaetsstrasse 1, 40225 Duesseldorf, Germany; Departments of Medicine and Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115; and Analytical and Applied...
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- Helmut Sies
- Department of Nutrition, University of California, One Shields Avenue, 3150E Meyer Hall, Davis, CA 95616; Division of Cardiology, Pulmonology, and Vascular Medicine, Heinrich-Heine University, Moorenstrasse 5, 40225 Duesseldorf, Germany; Institute of Biochemistry and Molecular Biology, Heinrich-Heine University, Universitaetsstrasse 1, 40225 Duesseldorf, Germany; Departments of Medicine and Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115; and Analytical and Applied...
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- Catherine Kwik-Uribe
- Department of Nutrition, University of California, One Shields Avenue, 3150E Meyer Hall, Davis, CA 95616; Division of Cardiology, Pulmonology, and Vascular Medicine, Heinrich-Heine University, Moorenstrasse 5, 40225 Duesseldorf, Germany; Institute of Biochemistry and Molecular Biology, Heinrich-Heine University, Universitaetsstrasse 1, 40225 Duesseldorf, Germany; Departments of Medicine and Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115; and Analytical and Applied...
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- Harold H. Schmitz
- Department of Nutrition, University of California, One Shields Avenue, 3150E Meyer Hall, Davis, CA 95616; Division of Cardiology, Pulmonology, and Vascular Medicine, Heinrich-Heine University, Moorenstrasse 5, 40225 Duesseldorf, Germany; Institute of Biochemistry and Molecular Biology, Heinrich-Heine University, Universitaetsstrasse 1, 40225 Duesseldorf, Germany; Departments of Medicine and Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115; and Analytical and Applied...
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- Malte Kelm
- Department of Nutrition, University of California, One Shields Avenue, 3150E Meyer Hall, Davis, CA 95616; Division of Cardiology, Pulmonology, and Vascular Medicine, Heinrich-Heine University, Moorenstrasse 5, 40225 Duesseldorf, Germany; Institute of Biochemistry and Molecular Biology, Heinrich-Heine University, Universitaetsstrasse 1, 40225 Duesseldorf, Germany; Departments of Medicine and Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115; and Analytical and Applied...
書誌事項
- 公開日
- 2006-01-17
- DOI
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- 10.1073/pnas.0510168103
- 公開者
- National Academy of Sciences
この論文をさがす
説明
<jats:p> Epidemiological and medical anthropological investigations suggest that flavanol-rich foods exert cardiovascular health benefits. Endothelial dysfunction, a prognostically relevant key event in atherosclerosis, is characterized by a decreased bioactivity of nitric oxide (NO) and impaired flow-mediated vasodilation (FMD). We show in healthy male adults that the ingestion of flavanol-rich cocoa was associated with acute elevations in levels of circulating NO species, an enhanced FMD response of conduit arteries, and an augmented microcirculation. In addition, the concentrations and the chemical profiles of circulating flavanol metabolites were determined, and multivariate regression analyses identified (–)-epicatechin and its metabolite, epicatechin-7- <jats:italic>O</jats:italic> -glucuronide, as independent predictors of the vascular effects after flavanol-rich cocoa ingestion. A mixture of flavanols/metabolites, resembling the profile and concentration of circulating flavanol compounds in plasma after cocoa ingestion, induced a relaxation in preconstricted rabbit aortic rings <jats:italic>ex vivo</jats:italic> , thus mimicking acetylcholine-induced relaxations. <jats:italic>Ex vivo</jats:italic> flavanol-induced relaxation, as well as the <jats:italic>in vivo</jats:italic> increases in FMD, were abolished by inhibition of NO synthase. Oral administration of chemically pure (–)-epicatechin to humans closely emulated acute vascular effects of flavanol-rich cocoa. Finally, the concept that a chronic intake of high-flavanol diets is associated with prolonged, augmented NO synthesis is supported by data that indicate a correlation between the chronic consumption of a cocoa flavanol-rich diet and the augmented urinary excretion of NO metabolites. Collectively, our data demonstrate that the human ingestion of the flavanol (–)-epicatechin is, at least in part, causally linked to the reported vascular effects observed after the consumption of flavanol-rich cocoa. </jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 103 (4), 1024-1029, 2006-01-17
National Academy of Sciences
