Chromatographically isolated CD63 <sup>+</sup> CD81 <sup>+</sup> extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI

DOI Web Site 4 Citations
  • Dong-ki Kim
    Institute for Regenerative Medicine at Scott & White, College of Medicine, Texas A&M Health Science Center, Temple, TX 76502
  • Hidetaka Nishida
    Institute for Regenerative Medicine at Scott & White, College of Medicine, Texas A&M Health Science Center, Temple, TX 76502
  • Su Yeon An
    Institute for Regenerative Medicine at Scott & White, College of Medicine, Texas A&M Health Science Center, Temple, TX 76502
  • Ashok K. Shetty
    Institute for Regenerative Medicine at Scott & White, College of Medicine, Texas A&M Health Science Center, Temple, TX 76502
  • Thomas J. Bartosh
    Institute for Regenerative Medicine at Scott & White, College of Medicine, Texas A&M Health Science Center, Temple, TX 76502
  • Darwin J. Prockop
    Institute for Regenerative Medicine at Scott & White, College of Medicine, Texas A&M Health Science Center, Temple, TX 76502

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<jats:title>Significance</jats:title> <jats:p>It has gradually been recognized that the vesicles secreted by cells are a major means by which cells communicate with each other. This recognition has stimulated interest in using vesicles to deliver therapeutic agents. The results presented here address several limitations to progress in the field by developing protocols to produce and isolate large numbers of extracellular vesicles (EVs) from stem-like cells found in the bone marrow. The isolated EVs were found to reduce the adverse effects of traumatic injury to the brain in mice.</jats:p>

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