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- Wenhua Xue
- Department of Pharmacy The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China
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- Zhirui Fan
- Department of Oncology Cancer Center, The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China
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- Lifeng Li
- Department of Oncology Cancer Center, The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China
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- Jingli Lu
- Department of Pharmacy The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China
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- Yunkai Zhai
- Center of Telemedicine, The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China
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- Jie Zhao
- Department of Pharmacy The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China
書誌事項
- 公開日
- 2018-10-30
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/jcp.27293
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>The chemokine system is a complex arrangement of molecules that attract leukocytes to the site of injury or inflammation. This chemotactic behavior gives the system the name “Chemokine.” The intricate and redundant nature of the chemokine system has made it a subject of ongoing scientific investigation. Obesity is characterized as low‐grade systemic or chronic inflammation that is responsible for the release of cytokines, adipokines, and chemokines. Excessive tissue fat expansion triggers the release of chemokines, which in turn attract various leukocytes and activate the resident immune surveillance system, eventually leading to worsening of obesity and other related comorbidities. To date, 50 chemokines and 20 chemokine receptors that belong to the G‐protein‐coupled receptor family have been discovered, and over the past two decades, the physiological and pathological roles of many of these chemokines and their receptors have been elucidated. The objective of this review is to present an update on the link between chemokines and obesity under the light of recent knowledge.</jats:p>
収録刊行物
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- Journal of Cellular Physiology
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Journal of Cellular Physiology 234 (4), 3336-3346, 2018-10-30
Wiley