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- Michael T. Laub
- Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139;
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- Mark Goulian
- Department of Biology and Department of Physics, University of Pennsylvania, Philadelphia, Pennsylvania 19104
説明
<jats:p> Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions. In the prototypical two-component system, a sensor histidine kinase catalyzes its autophosphorylation and then subseqeuntly transfers the phosphoryl group to a response regulator, which can then effect changes in cellular physiology, often by regulating gene expression. The utility of these signaling systems is underscored by their prevalence throughout the bacterial kingdom and by the fact that many bacteria contain dozens, or sometimes hundreds, of these signaling proteins. The presence of so many highly related signaling proteins in individual cells creates both an opportunity and a challenge. Do cells take advantage of the similarity between signaling proteins to integrate signals or diversify responses, and thereby enhance their ability to process information? Conversely, how do cells prevent unwanted cross-talk and maintain the insulation of distinct pathways? Here we address both questions by reviewing the cellular and molecular mechanisms that dictate the specificity of two-component signaling pathways. </jats:p>
収録刊行物
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- Annual Review of Genetics
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Annual Review of Genetics 41 (1), 121-145, 2007-12-01
Annual Reviews