Exploration of Nitrate Reductase Metabolic Pathway in<i>Corynebacterium pseudotuberculosis</i>

  • Sintia Almeida
    Institute of Biologic Sciences, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil
  • Cassiana Sousa
    Institute of Biologic Sciences, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil
  • Vinícius Abreu
    Center for Nuclear Energy in Agriculture, University of Sao Paulo, 13400-970 Piracicaba, SP, Brazil
  • Carlos Diniz
    Institute of Biologic Sciences, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil
  • Elaine M. S. Dorneles
    Escola de Veterinária, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
  • Andrey P. Lage
    Escola de Veterinária, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
  • Debmalya Barh
    Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, West Bengal, India
  • Vasco Azevedo
    Institute of Biologic Sciences, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil

抄録

<jats:p>Based on the ability of nitrate reductase synthesis,<jats:italic>Corynebacterium pseudotuberculosis</jats:italic>is classified into two biovars: Ovis and Equi. Due to the presence of nitrate reductase, the Equi biovar can survive in absence of oxygen. On the other hand, Ovis biovar that does not have nitrate reductase is able to adapt to various ecological niches and can grow on certain carbon sources. Apart from these two biovars, some other strains are also able to carry out the reduction of nitrate. The enzymes that are involved in electron transport chain are also identified by in silico methods. Findings about pathogen metabolism can contribute to the identification of relationship between nitrate reductase and the<jats:italic>C. pseudotuberculosis</jats:italic>pathogenicity, virulence factors, and discovery of drug targets.</jats:p>

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